Bithorax 复合体中的增强子/启动子相互作用-猫眼课题宝

Bithorax 复合体中的增强子/启动子相互作用

批准号：

2857056

负责人：

JUMIN ZHOU

金额：

$3.84万

依托单位：

UNIVERSITY OF CALIFORNIA BERKELEY

依托单位国家：

美国

项目类别：

财政年份：

1999

资助国家：

美国

项目状态：

未结题

起止时间：

1999-01-01 至

来源：

https://reporter.nih.gov/project-details/2857056

关键词：

Drosophilidae gene expression genetic enhancer element genetic mapping genetic promoter element genetic regulation molecular cloning mutant nucleic acid sequence regulatory gene

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中文摘要

翻译

拟议研究的目的是了解的基本原则

英文摘要

The goal of the proposed studies is to understand the basic principles of enhancer-promoter interactions in complex genetic loci with particular emphasis of the Abd-B region of the Drosophila bithorax complex (BX-C). The Abd-B gene contains 5 parasegmental-specific regulatory regions, or infra abdominal (iab) regions that span over approximately 100 kb of DNA. Two class of specialized DNA elements may might regulate enhancer- promoter interaction and to keep neighboring cis regulatory regions separates; augmenter DNA might facilitate enhancer-promoter interaction over long distances. An insulator DNA element, Front abdominal-7 (Fab-7), has been characterized between iab-6 and iab-7. The specific aims of the proposed study is to identify trans-acting factors for Fab-7 through genetic screens, and to identify and characterize augmenter elements that facilitate long range enhancer promoter interactions.

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