MICROBICIDAL COATINGS FOR DENTAL UNIT WATERLINES

越来越多的人认识到，生物膜的形成对牙科单位的水线有重大影响。从主要水源到牙科诊所或以前患者口腔菌群的细菌附着在水线的管腔壁上，并在几周或几个月的时间里形成密集的生物膜堆积。该项目的目标是利用BSI的专有光固定化技术开发一种用于牙科单位水线的抗菌表面涂层。该项目将使用烷基季铵盐基和膦酸基作为杀菌剂。氟烷基将被用来减少生物污垢。第一阶段的目标是合成含氟烷基和不含氟烷基的烷基季铵盐和膦涂层试剂；展示光烷基季铵盐试剂的杀菌活性；将涂层试剂固定在牙科水线基质上；检测改性材料在减少细菌黏附和定植方面的有效性；使用反应器系统评估细菌生物膜在改性材料上的发展和积累；确定改性材料是否在体外具有毒性；以及展示杀菌和防污垢涂层对液体洗涤和湿/干循环作用力的稳定性。该项目的长期目标是在水线表面开发耐用的、自我消毒和防污的薄膜。拟议的商业应用：微生物定植和生物膜形成仍然是牙科和制药行业、医疗保健和公共住宿以及海洋船舶和固定结构行业的主要成本、人类健康和产品质量问题。成功地将BSI的涂层技术与杀菌和防污涂层聚合物配合使用，将显著提高我们保持表面微生物质量的能力。

There is increasing recognition that biofilm formation has a significant impact on dental unit waterlines. Bacteria from the main water source to dental clinics or from previous patient's oral flora adhere to the luminal walls of the waterlines and become a dense accumulation of biofilm over a period of weeks or months. The goal of this project is to develop an antimicrobial surface coating for dental unit waterlines using BSI's proprietary photoimmobilization technology. This project will employ alkyl quiaternary ammonium and phasphonium groups as the microbicidal agent. Fluoroalkyl groups will be used to reduce biofouling. The Phase I objectives are to synthesize alkyl quaternary ammonium and phosphonium coating reagents with and without fluoroalkyl groups; demonstrate microbicidal activity of the photoalkyl quat reagents; immobilize the coating reagents on dental waterline substrates; examine the efficacy of the modified materials in reducing bacterial adherence and colonization; evaluate bacterial biofilm development and accumulation on modified materials using reactor systems; determine whether modified materials are toxic in vitro; and demonstrate stability of microbicidal and antifouling coatings against liquid wash and wet/dry cycle forces. The long-range goal of this project is to develop durable, self-sterilizing, and antifouling films on waterline surfaces. PROPOSED COMMERCIAL APPLICATION: Microbial colonization and biofilm formation remains a major cost, human health, and product quality problem for dental and pharmaceutical industries, health care and public lodging, and marine vessel and stationary structure industries. Successful use of BSI's coating technology with microbicidal and antifouling coating polymers will significantly improve our ability to maintain microbial quality of surfaces.