ENGINEERED OPSONINS FOR WHOLE CELL TUMOR VACCINES

不同的小组正在开发一些策略，利用自体肿瘤细胞中的基因转移来创造治疗性肿瘤疫苗。然而，基因转移带来了一些技术问题，这些问题限制了这种疫苗的临床用途和商业可行性。作为另一种选择，该项目将识别一种嵌合的GPI连接分子，它可以提高免疫反应传入肢体中事件的效率。这种分子在制造肿瘤疫苗方面的效用将在小鼠模型中进行测试。拟议的商业应用：癌症疫苗的新技术

A number of strategies are under development by various groups for the creation of therapeutic tumor vaccines using gene transfer in autologous tumor cells. However, gene transfer entails a number of technical problems that limit both the clinical utility and commercial viability of such vaccines. As an alternative, this project will identify a chimeric GPI-linked molecule that improves the efficiency of events in the afferent limb of the immune response. The utility of this molecule in the creation of tumor vaccines will be tested in mouse models. PROPOSED COMMERCIAL APPLICATIONS: Novel technology for cancer vaccines