HISTOPATHOLOGIC STUDIES OF ASTHMA

哮喘通常被视为一种慢性炎症的呼吸道疾病。 在发病机制中起着重要作用。一些研究使用了 支气管肺泡灌洗(BAL)通过检测 通过这个程序回收的液体和细胞。这种方法具有 显示多种炎症介质的水平，如组胺， 肺泡灌洗液中的类胰蛋白酶、前列腺素、白三烯和激动素 哮喘受试者与正常受试者相比，以及 炎性细胞的数量，如肥大细胞和嗜酸性粒细胞。其中一些 这些异常与疾病的严重程度直接相关， 肺功能下降，呼吸道多动。目的 这项研究是为了检查炎症之间的关系，评估 支气管肺泡灌洗液中细胞和介质的检测与炎症 经支气管镜活检评估呼吸道功能。

Asthma is usually viewed as an airways disease where chronic inflammation plays an important role in pathogenesis. Some studies have used bronchoalveolar lavage (BAL) to assess airway inflammation by examining the fluids and cells recovered by this procedure. This approach has demonstrated levels of multiple inflammatory mediators such as histamine, tryptase, prostaglandins, leukotrienes, and kinins in BAL fluids from asthmatic subjects compared to normal subjects, as well as increased numbers of inflammatory cells, such as mast cells and eosinophils. Some of these abnormalities have been directly correlated with disease severity, decreased pulmonary function, and airway hyperactivity. The purpose of this study is to examine the relationship between inflammation assessed by examination of cells and mediators in BAL fluids and inflammation in airways assessed by bronchial biopsy.