HISTOPATHOLOGIC STUDIES OF ALLERGIC INFLAMMATION OF AIRWAYS

哮喘是一种常见的呼吸道疾病，炎症在其中起着中心作用。 在发病机制中的作用。虽然哮喘的相关性已经很好地建立， 过敏性炎症导致哮喘的机制还没有 要完全定义。这个项目将检查生物化学和细胞 节段性过敏原攻击模型中的炎症机制 过敏性哮喘患者的气道。将评估炎症 通过检查支气管肺泡灌洗获得的细胞和液体， 通过支气管活检获得的组织。过敏反应的动力学 将在一小时至两周内检查气道的反应 以下挑战和炎症事件的相互关系 包括介质释放、细胞募集、细胞因子基因表达 将评估细胞因子产物的出现和抗体产生。 TH 1/TH 2淋巴细胞的募集、抗原特异性和功能 人口，将是研究的重点。最后，效果 局部皮质类固醇对气道功能、炎症和 将检查对变应原攻击的反应。这些研究将产生 过敏性炎症和哮喘之间的关系 这可以指导治疗方法。

Asthma is a common airways disease in which inflammation plays a central role in pathogenesis. While the association of asthma is well established, the mechanisms by which allergic inflammation result in asthma have yet to be fully defined. This proosal will examine the biochemical and cellular mechanisms of inflammation in the model of segmental allergen challenge of the airways in allergic asthmatic subjects. Inflammation will be assessed by examination of cells and fluids obtained by bronchoalveolar lavage and of tissues obtained by bronchial biopsy. The kinetics of the allergic response of the airways will be examined from one hour to two weeks following challenge and the inter-relationship of inflammatory events including mediator release, cell recruitment, cytokine gene expression, appearance of cytokine products, and antibody production will be assessed. Recruitment, antigen specificity, and function of TH1/TH2 lymphocyte populations, will be a particular focus of the study. Finally, the effect of topical corticosteroids on airway function, inflammation, and the response to allergen challenge will be examined. These studies wil yield insights into the relatonship between allergic inflammation and asthma which can guide approaches to treatment.