EVALUATION OF GH EFFECTS ON REE AND BODY COMPOSITION OF CHILDREN WITH PWS

我们寻求支持来研究生长激素的合成代谢作用 (Gh)对遗传性肥胖儿童的身体成分的影响， Prader-Willi综合征(PWS)。我们已经开始研究新陈代谢 生长激素对体成分包括线性生长率、骨量的影响 密度、营养素摄入量和心血管危险因素，包括 静息能量消耗、瘦体重和体脂百分比、肌肉 力量和灵活性，肺功能，以及碳水化合物和 脂类代谢。这一患者群体提供了一个已知的模型 遗传性肥胖的风险因素和生长的代谢后果 荷尔蒙缺乏。最近的研究显示了合成代谢作用。 生长激素改善身体成分，同时减少肥胖和其他 心血管危险因素。 我们已经获得了同行评议的资金，以获得全面的 对照研究，这提供了一个参与的独特机会 多学科临床研究。但是，从这个时候开始， 临床资助奖，我们为这项研究增加了一个额外的方面： 静息能量消耗(REE)的测量。充足的资金 已经获得了实现大部分研究目标的能力，但 不是用来测量稀土元素。利用呼吸法测定稀土元素 商的测量在科学上具有重要的价值 研究方案，并将直接适用于未来的调查 生长激素等合成代谢激素对机体代谢影响的研究进展 组成。这项评估将提供以下重要信息： 导致PWS身体成分异常的因素，同时进一步 使该研究员做好准备，以便在未来对 生长激素对身体成分和肥胖的代谢影响。

We seek support to investigate the anabolic effects of growth hormone (GH) on body composition in children with a genetic form of obesity, Prader-Willi Syndrome (PWS). We have begun to study the metabolic effects of GH on body composition including linear growth rate, bone density, nutrient intake, and cardiovascular risk factors including resting energy expenditure, lean body mass and percent body fat, muscle strength and agility, pulmonary function, as well as carbohydrate and lipid metabolism. This patient population provides a model with known risk factors for genetic obesity, and metabolic consequences of growth hormone deficiency. Recent investigations have shown anabolic effects of GH improving body composition, while decreasing obesity and other cardiovascular risk factors. We have been awarded peer reviewed funding for a comprehensive controlled study, which provides a unique opportunity to engage in multi-disciplinary clinical research. However, since the time of this clinical grant award, we have added an additional facet to the study: the measurement of resting energy expenditure (REE). Sufficient funds have been obtained to accomplish the majority of study objectives, but not for REE measurements. The measurement of REE utilizing respiratory quotient measurements contributes substantial scientific value to the study protocol, and will be directly applicable to future investigations of metabolic effects of GH and other anabolic hormones on body composition. This assessment will provide important information about factors leading to abnormal body composition in PWS, while further preparing the fellow to conduct important future investigations of the metabolic effects of GH on body composition and obesity.