AUTOCLAVABLE SENSOR FOR IN SITU BIOREACTOR MONITORING

这个小企业创新研究第一阶段项目将展示一种独特的葡萄糖传感水凝胶膜的可行性，在第二阶段的努力中，将其纳入生物处理反应器中连续原位葡萄糖监测的创新传感器中，并且与目前的在线监测技术相比，由于减少了分析时间、复杂性和微生物污染风险，从而提高了性能和成本效益。拟议的商业应用：今天，现代生物技术的成功应用证明了各种各样的产品，从特种化学品、聚合物、食品到治疗药物，这些产品是通过在各种细胞培养系统中使用重组DNA方法生产的。不断需要开发和实施一种新的传感系统来有效地控制和优化这些生物过程。在生物反应器和/或发酵罐中使用可靠稳定的葡萄糖传感器是有潜在市场的。通过我们与几家制药/生物技术公司的初步接触，反应非常积极。通过与这些公司和学术机构建立战略联盟来测试和评估传感系统，传感器将迅速适应不同的工业生物反应器设置。

This Small Business Innovation Research Phase I project will demonstrate the feasibility of a unique glucose-sensing hydrogel membrane to be incorporated, in a phase II effort, into an innovative sensor for continuous in situ glucose monitoring in bioprocessing reactors and improved performance and cost effectiveness being realized as aq result of reduced analysis time, complexity, and risk of microbial contamination as compared to the current on-line monitoring technologies. PROPOSED COMMERCIAL APPLICATIONS: Today, success in the applications of modern biotechnological techniques is evidenced by the variety of products ranging from specialty chemicals, polymers, and food to therapeutic drugs, produced by using recombinant DNA methodologies in various cell cultured systems. There is a constant need to develop and implement a new sensing system to effectively control and optimize these biological processes. The potential market for the use of a reliable stable glucose sensor for monitoring in bioreactors and/or fermenters exists. Through our initial contact with several pharmaceutical/biotechnology companies, the response is overwhelmingly positive. By forming a strategic alliance with these companies and academic institutions to test and evaluate the sensing system, the sensor will be quickly adapted for different industrial bioreactor settings.