NORTHWEST CANCER GENETICS NETWORK

西北癌症遗传学（Northwest Cancer Genetics） 网络（NWCGN）-响应癌症遗传学网络（RFA）提出 #97004）-将成为研究癌症遗传基础的资源 敏感性，在医疗实践中适当使用这些信息， 以及癌症遗传学知识对公众健康的影响。 到 为了实现这些目标，我们将1）参与发展， 管理的CGN和2）将有助于CGN的登记册， 对癌症筛查感兴趣和/或处于确定风险水平的个人 治疗癌症 主要关注的是对遗传学感兴趣的个人。 从地区遗传诊所（包括现有的 我们参与的网络），通过医生和自我推荐。 在 以确保高风险人员的征聘具有代表性和效率 个人，将为先证者建立一个基于人群的登记处 与特定癌症的诊断，他们的家庭成员和人口， sample. 所有参与者将完成一个关于家庭的结构化面试 癌症史，病史和其他被认为影响的因素 癌症风险。 所有参与者将获得个性化的风险 信息. NWCGN为CGN带来了临床方面的重要专业知识 遗传学，分子遗传学，分子生物学，流行病学， 生物统计学、经济学、伦理学、咨询、初级保健和心理学。 这种学科组合对于支持所需的基础设施至关重要 收集寻求基因检测的个人的关键数据，以及 那些有已知家族史的人

DESCRIPTION: (Applicant's Description) The Northwest Cancer Genetics Network (NWCGN) - proposed in response to the Cancer Genetics Network (RFA #97004) - will be a resource for studies of the genetic basis of cancer susceptibility, the appropriate use of this information in medical practice, and the impact of knowledge of cancer genetics on public health. To accomplish these aims, we will 1) participate in the development and management of the CGN and 2) will contribute to the CGN a register of individuals interested in cancer screening and/or at defined levels of risk for cancer. The primary focus will be on individuals interested in genetic testing identified from the area genetic clinics (including an existing network in which we participate), via physicians and as self-referrals. In order to ensure representative and efficient recruitment of high-risk individuals, a population-based registry will be established for probands with diagnoses of specific cancers, their family members, and a population sample. All participants will complete a structured interview on family history of cancer, medical history, and other factors thought to influence cancer risk. All participants will be provided individualized risk information. The NWCGN brings to the CGN significant expertise in clinical genetics, molecular genetics, molecular biology, epidemiology, biostatistics, economics, ethics, counseling, primary care and psychology. This mix of disciplines is essential to support the infrastructure required to collect crucial data on individuals seeking genetic testing, as well as those with known family histories.