GLUCOSE SENSITIVE ARTIFICIAL RECEPTORS FOR INSULIN

描述（改编自申请人摘要）： 胰岛素依赖型（I型）糖尿病理论上可以通过 胰岛素的管理。 不幸的是，目前的周期性方法 胰岛素注射提供了与正常胰岛素差的近似值 输出. 反馈控制释放胰岛素进入血液循环， 一种可用于将血糖浓度维持在 期望的水平。 这项试点研究（R21应用）旨在 展示了一种新的方法在合成新型 用于人造胰腺的高分子材料。 具体而言，在本申请中，将进行模型研究，以建立 可以结合这种聚合物上的葡萄糖缀合物的聚合物受体 受体。 如果申请人能够成功证明 这个概念，它打开了使用相同方法的可能性， 糖基化胰岛素的聚合受体的合成。 这样的聚合物， 如果研制成功，可以想象， 人工胰腺

DESCRIPTION (Adapted from applicant's abstract): The symptoms of insulin-dependent (type I) diabetes could theoretically be corrected by the administration of insulin. Unfortunately, the current method of periodic insulin injection provides a poor approximation of the normal insulin output. Feedback controlled release of insulin into blood circulation is one approach that can be used to maintain blood glucose concentrations at desired levels. This pilot study (R21 application) is aimed at demonstrating the utility of a novel approach to the syntheses of new types of polymeric materials for the development of an artificial pancreas. Specifically, in this application model studies will be performed to build polymeric receptors that can bind the glucose conjugates on such polymeric receptors. If the applicant can successfully demonstrate the feasibility of the concept, it opens the possibility of using the same method for the syntheses of polymeric receptors for glycosylated insulin. Such polymers, if successfully developed, could conceivably be used as an implantable artificial pancreas.