DEVELOPING AN UNDERSTANDING OF ASYMMETRIC INDUCTION

这一建议是针对理解的机制， 催化不对称过程和手性催化剂的设计与开发 过渡金属基催化剂用于不对称催化。 手性合成技术的影响是相当多样的， 对药物化学和制药领域至关重要 化学. 本提案的具体目的是：（一）了解 手性双磺酰胺结构、性质和反应性 配合物及其在不对称催化中的作用，（II）合成 （双磺酰氨基）TiX 2配合物（X=F，Cl，Br）及其碱加合物， (III)目的：探索合成，结构和反应活性 多用途的双磺酰氨基钛双酰胺络合物 用于制备（双磺酰氨基）钛物质的中间体， 和（VI）开发六齿双磺酰胺钛化合物， 应用于不对称催化。 我们长远的目标是 了解手性转移的机制， 建立了不对称流程，以便为 合理设计新的不对称反应。 不对称的过程 合成已经被对光学材料的需求的增加所驱动。 纯材料。 因此，这一领域的大部分焦点已经转向 涉及在不对称方法中筛选催化剂的改进方法。 然而，很少有人了解催化系统， 已知的结构或催化剂的操作。 我们用来实现目标的方法包括独立的 不对称反应中催化剂的合成及其应用 结构（包括结构）。这些复合物是 在不对称过程中进行测试，以评估其可行性， 催化剂的

This proposal is directed toward the understanding of the mechanisms of catalytic asymmetric processes and the design and development of chiral transition metal based catalysts to be used in asymmetric catalysis. The impacts of chiral synthetic technology are quite diverse and are critical to the fields of medicinal chemistry and pharmaceutical chemistry. The specific aims of this proposal are: (I) To understand the structure, properties and reactivity of chiral bissulfonamido complexes and their role in asymmetric catalysis, (II) To synthesize (bissulfonamido)TiX2 complexes (X=F, C1, Br) and their base adducts, (III) To explore the synthesis, structure and reactivity of bissulfonamido titanium bisamide complexes which are versatile intermediates for the preparation of (bissulfonamido)titanium species, and (VI) to develop hexadentate titanium bissulfonamide compounds and apply them to asymmetric catalysis. Our long-term objective is to develop an understanding of the mechanism of chirality transfer in established asymmetric processes in order to build a foundation for the rational design of new asymmetric reactions. The course of asymmetric synthesis has been driven by an increase in the demand for optically pure materials. As result, much of the focus of this field has turned to improving methods to screen catalysts in asymmetric processes. However, rarely is the catalytic system understood and often little is known of the structure or the operation of the catalyst. The methods that we use to accomplish our goals involve the independent synthesis of proposed catalysts in asymmetric reactions and their characterization (including structurally). These complexes are then tested in the asymmetric process to evaluate their viability as catalysts.