Elucidating the roles of steroid receptors in mitochondria

本项目旨在阐明新发现的类固醇受体在线粒体功能中的作用。该项目将描述它们对细胞呼吸、氧化应激和炎症诱导的影响。通过定义健康状态下的这些过程，以及对感染和烟雾暴露等常见环境挑战的反应，该项目将描述正常身体激素和给药类固醇如何发挥作用的全新过程的基本生物学特征。这可能最终导致新的和更有效的方法来控制炎症，这将对哺乳动物的健康产生重大好处，并改善医疗保健和农业成果。

This project aims to elucidate the roles of newly discovered steroid receptors in the functions of mitochondria. The project will characterise their impact on cellular respiration, oxidative stress, and the induction of inflammation. By defining these processes in the healthy state and in response to common environmental challenges of infection and smoke exposure, the project will characterise the fundamental biology of entirely new processes of how normal body hormones and administered steroids may function. This may eventually lead to new and more effective ways to control inflammation that will have significant benefits to mammalian health and improve health care and agriculture outcomes.