Breaking through the Gram-negative cell barrier

这个项目旨在发展革兰氏阴性细菌细胞膜的基础知识，它起着小分子的渗透屏障的作用。将创新的功能基因组学与生物化学相结合，该项目将确定小分子如何穿过细胞膜，以及它们需要这样做的化学性质。一些革兰氏阴性细菌是人类的病原体，会导致严重的感染，而另一些则用于生物技术，用于生物合成化学生产或生物修复。该项目预计将有助于未来新抗生素的开发，并协助设计用于生物技术应用的菌株。

This project aims to develop fundamental knowledge of the cell envelope in Gram-negative bacteria, which functions as a permeability barrier to small molecules. Combining innovative functional genomics with biochemistry, this project will determine how small molecules can pass across the cell envelope, and the chemical properties that they need to do so. Some Gram-negative bacteria are human pathogens and cause serious infections, whereas others are used in biotechnology for biosynthetic chemical production or bioremediation. This project expects to help the future development of new antibiotics and assist in the design of strains to be used in biotechnological applications.