QUANTITATIVE ANALYSIS OF A METHOD DEVELOPMENT FOR CANN

近二十年来，国家药物滥用研究所及其 其前身是麻醉品和药物滥用研究中心，NIMH， 为研究药物滥用问题的科学界提供了 真实的、标准化的受控研究药物供应， 化学品和分析支持。其中包括大麻香烟， 已知的，已知的致幻剂，海洛因，安非他明，大麻素，以及许多 临床和实验室研究所必需的其他药物。 除了提供药物外，NIDA还通过以下途径提供分析服务： 通过GC-质谱法和放射免疫测定法（RIA）进行样品分析。 放射免疫分析及相关方法提供了一种快速、灵敏和特异的检测方法 分析生物体液中药物的技术。的 Δ 9-THC，11-NOR-THC-9-羧酸（9-羧基- 四氢大麻酚）大麻素、苦啡肽（nociceptin）和其他滥用药物， 相关化合物需要用于各种研究， 吸大麻的药代动力学和药效学，药理学 大麻素和其他滥用药物的毒理学。通过这个 合同NIDA计划（1）开发放射免疫分析测定法 (RIA)或用于大麻素、大麻酰胺、大麻素的任何其它相关方法 FQ（痛敏素）和其他滥用药物及相关化合物， （2）协助研究人员进行以下工作： 分析他们的研究样本，以获得上述药物，以及（3）提供 分析试剂盒，以那些研究人员谁愿意在他们的 自己的实验室。

For nearly two decades, the National Institute on Drug Abuse and it's predecessor, Center for Studies of Narcotics and Drug Abuse, NIMH, has provided the scientific community working on problems of drug abuse with authentic, standardized supplies of controlled research drugs and chemicals and analytical support. These included marijuana cigarettes, known, known hallucinogens, heroin, amphetamines, cannabinoids, and many other drugs essential for both clinical and laboratory research studies. Besides supplying drugs, NIDA also provided analytical services through sample analysis by GC-Mass spectroscopy and radioimmunoassay (RIA). The RIA and related methods provide a rabid, sensitive and specific assay technique for the analysis of drugs in biological fluids. The quantification of delta9-THC, 11-NOR-THC-9-carboxylic acid (9-carboxyl- THC) anandamide, orphanin FQ (nociceptin), and other drugs of abuse and related compounds is required for a variety of studies involving pharmacokinetics and pharmacodynamics of marijuana smoking, pharmacology and toxicology of cannabinoids, and other drugs of abuse. Through this contract NIDA plans (1) to develop analytical assays by radioimmunoassay (RIA) or any other related methods for cannabinoids, anandamide, orphanin FQ (nociceptin), and other drugs of abuse and related compounds as required by the Project Officer, (2) to assist research investigators in analyzing their research samples for afore said drugs, and (3) to supply assay kits to those researchers who would like to perform assays in their own laboratories.