BIOPHYS STUD OF PROTEINS, NUCLEIC ACIDS, AND VIRUSES

普渡大学的生物物理培训补助金继续强调结构生物学，同时增加了涉及和影响结构生物学的其他学科的教师导师的代表性。在此期间，指导教师从19名增加到22名，所有成员都来自六个不同的部门，全部或部分参与结构生物学的某些方面。两个新院系加入，来自生物、生物化学和物理的导师数量也有所增加。基本的核心研究设备，x射线衍射仪、核磁共振光谱仪和电子显微镜，得到了很大的扩展和改进。六个重叠的研究兴趣领域（可溶性蛋白的结构-功能、膜蛋白和毒素、核酸结构-功能和蛋白质-核酸相互作用、病毒结构-功能、计算方法和金属蛋白）可以通过至少四名教员的最小教员群规模来确定。这些互动导致了53篇出版物，涉及至少两名教员，在两个资助期间，13名生物物理学学员也参与了其中。在此期间，过去和现在的生物物理学已经贡献了132个出版物和演讲和专业会议的摘要。过去的受训者中有很大一部分目前正在大学或工业界积极从事研究工作。在上一个赠款期间，学员中代表人数不足的少数民族和妇女的人数相当可观。一个由学生和教师参与的关于重要伦理和科学问题的讨论小组受到热烈欢迎。研究生课程的课程设置有所改进，并保持了对量化的高度重视。该计划的新的教育方面包括每年举办一次以学生为中心的生物物理学研讨会，已经举办了三次，以及由不同导师就即将举行的研讨会的核心概念进行的研讨会前“生物物理学讨论”。每周的结构生物学研讨会和双周的结构生物学杂志俱乐部继续成为定期的研究和培训活动。

The biophysical training grant at Purdue University has continued its strong emphasis on structural biology, while increasing the representation of faculty mentors from other disciplines which involve and affect structural biology. The mentoring faculty has increased from 19 to 22 in this period, with all members from six different departments either fully or partly involved in some aspect of structural biology. Two new departments are represented, and the number of mentors from biology, biochemistry, and physics as increased. The basic core research equipment, X-ray diffractometers, NMR spectrometers, and electron microscopes, has expanded and improved greatly. Six areas of overlapping research interests (structure-function of soluble proteins, membrane proteins and toxins, nucleic acid structure-function and protein-nucleic acid interactions, virus structure-function, computational approaches and metalloproteins) can be identified with a minimum faculty cluster size of at least four faculty members. These interactions had led to fifty-three publications involving at least two faculty members over the two grant periods in which thirteen biophysics trainees have also participated. During this time, past and current biophysics have contributed to 132 publications and abstracts of presentations and professional meetings. A high fraction of past trainees are currently working actively in research at universities or in industry. During the last grant period, there has been important and significant representation among the trainees from under-represented minorities and women. A discussion group on important issues of ethics and science, involving both students and faculty, has been enthusiastically received. The graduate course curriculum has improved and maintained a high degree of emphasis on quantitation. New educational aspects of the program have been an annual-student oriented biophysics symposium, already presented three times, and pre-seminar "biophysical discussions" given by different mentors on central concepts to be presented in upcoming seminars. The weekly structural biology seminars and bi-weekly structural biology journal club have continued to be regular research and training events.