The transcriptome dynamics that refine eukaryotic gene expression

本项目旨在通过探索细胞如何通过改变RNA表达和加工来应对急性扰动，从而了解基因表达控制的基本机制。与基因组中编码的静态信息不同，在其中间RNA中编码的信息是短暂的、可塑的，并对环境和发育线索作出反应。该项目将使用包括RNA生物化学、下一代测序和生物信息学在内的新技术来回答长期存在的RNA加工问题。该项目预计将大大提高我们对基因表达控制机制的理解，使澳大利亚成为RNA生物学领域的世界领导者。

This project aims to understand the fundamental mechanisms of gene expression control, by exploring how cells respond to acute perturbation with changes to RNA expression and processing. Unlike the static information encoded within the genome, the information encoded in its intermediary RNA, is transient, plastic and responsive to environmental and developmental cues. This project will use new technologies encompassing RNA-biochemistry, Next Generation Sequencing, and bioinformatics to answer long-standing questions in RNA processing. The project expects to significantly enhance our understanding of the mechanisms underpinning gene-expression control, benefitting Australia by positioning it as a world leader in the field of RNA Biology.