TRANSGENIC MOUSE MODEL EVALUATION

环境致癌计划（ECP）的总体研究目标 是为了深入了解环境因素 导致疾病。 通过调查选定的模型化学品的风险， 啮齿动物和人类，也许可以提高我们对 在啮齿动物模型系统中的诱变和致癌机制。 这 可能导致预测人类健康的相对风险， 环境化学品暴露，并能够识别或预测 具有相似性质的化学物质的影响。 因此， 目标是理解和应用在这一奋进中获得的知识， 预防人类疾病。 为了实现这些目标，该计划的使命是开发和验证 评估化学品对癌基因，抑制基因， 和其他关键的分子决定因素， 开发和验证方法，以快速评估毒理学和 致突变和非致突变化学品的致癌潜力。 履行 这一使命，这一合同应提供机会，调查 用于致癌、致突变以及分子生物学的转基因模型 问题研究 此外，还应考虑到更有效地评价 转基因菌株，以确定如果任何菌株将 对进一步深入研究和提供了解非常有用 肿瘤形成过程中的机制

The overall research goal of the Environmental Carcinogenesis Program (ECP) is to provide insight into the mechanisms by which environmental agents cause disease. By investigating selected model chemicals of risk to rodents and humans, it may be possible to improve out understanding of the mechanisms of mutagenesis and carcinogenesis in model rodent systems. This could lead to predicting the relative risk to human health for environmental chemical exposure and to be able to identify or predict affects of chemicals that possess similar properties. Thus, the overall goal is to understand and apply knowledge gained in this endeavor to the prevention of human disease. To achieve these goals, it is the Program's mission to develop and validate methods to assess the affects of chemicals on oncogenes, suppressor genes, and other critical molecular determinants in neoplastic processes and to develop and validate methods to rapidly assess the toxicologic and carcinogenic potential of mutagenic and nonmutagenic chemicals. To fulfill this mission, this contract shall provide the opportunity to investigate transgenic models for use in carcinogenic, mutagenic, as well as molelcular studies. In addition, it shall allow for the more efficient evaluation of transgenic strains in order to determine which if any of the strains would be most useful for further indepth studies and to provide an understanding of the mechanisms involved in the neoplastic process.