TRANSGENIC MOUSE MODEL EVALUATION

环境致癌计划(ECP)的总体研究目标 是为了洞察环境代理人 引发疾病。通过调查选定的有风险的化学物质模型 啮齿动物和人类，也许有可能提高对 在模型啮齿动物系统中的诱变和致癌机制。这 可能导致预测对人类健康的相对风险 环境中的化学品暴露，并能够识别或预测 具有类似性质的化学品的影响。因此，总体上， 目标是理解并将在这一努力中获得的知识应用于 预防人类疾病。 为了实现这些目标，该计划的任务是制定和验证 方法评估化学物质对癌基因、抑癌基因、 和其他在肿瘤过程中的关键分子决定因素 开发和验证方法以快速评估毒理学和 致突变和非致突变化学品的致癌潜力。履行 此次任务，本合同应提供调查的机会 用于致癌、致突变和分子生物学的转基因模型 学习。此外，它还应允许更有效地评估 转基因菌株，以确定哪些菌株会 对于进一步的深入研究和提供理解是非常有用的 肿瘤过程中涉及的机制。

The overall research goal of the Environmental Carcinogenesis Program (ECP) is to provide insight into the mechanisms by which environmental agents cause disease. By investigating selected model chemicals of risk to rodents and humans, it may be possible to improve out understanding of the mechanisms of mutagenesis and carcinogenesis in model rodent systems. This could lead to predicting the relative risk to human health for environmental chemical exposure and to be able to identify or predict affects of chemicals that possess similar properties. Thus, the overall goal is to understand and apply knowledge gained in this endeavor to the prevention of human disease. To achieve these goals, it is the Program's mission to develop and validate methods to assess the affects of chemicals on oncogenes, suppressor genes, and other critical molecular determinants in neoplastic processes and to develop and validate methods to rapidly assess the toxicologic and carcinogenic potential of mutagenic and nonmutagenic chemicals. To fulfill this mission, this contract shall provide the opportunity to investigate transgenic models for use in carcinogenic, mutagenic, as well as molelcular studies. In addition, it shall allow for the more efficient evaluation of transgenic strains in order to determine which if any of the strains would be most useful for further indepth studies and to provide an understanding of the mechanisms involved in the neoplastic process.