GORDON CONFERENCE ON POLYAMINES

申请人的描述（Applicant's Description） 多胺是细胞生长所必需的小脂肪族阳离子， 生存能力。 丰富的天然存在的多胺是亚精胺， 精胺，沿着二胺前体腐胺。 池的维护 是复杂的，并依赖于生物合成，催化剂和运输。 异常 积累与细胞生长的干扰有关，包括 癌 使用多胺代谢抑制剂的治疗性干预 关键酶和类似物在非洲昏睡病和 动物肿瘤模型。 目前正在调查这些模式，认为它们很有希望 在化学治疗和化学预防临床试验中使用抗肿瘤剂。 提交该提案是为了确保戈登研究的部分资金 多胺会议。 会议将提供一个场地， 研究人员之间的思想交流， 从基础细胞科学到临床应用。 接收的主题 该计划特别强调的是那些反映最近进展的计划， 外地 会议将在以下领域提供： 受复杂调节性改变或消除影响的完整生物体 过程提供了对这些过程的体内功能的深入了解 （转基因小鼠，小鼠遗传学）。 多胺在癌症中的作用及其对癌症的影响 将探索多胺类似物和关键酶抑制剂的应用 （癌症）。 酶结构的研究进展 多胺代谢提供了深入了解其功能机制 和潜在的干预策略（结构）。 多胺功能 完整的生物体和转录后调节将被探讨 （翻译和翻译后调节，多胺功能）。 的 多胺在细胞程序性死亡和膜相关性凋亡中的作用 功能将被描述（离子通道和运输，细胞凋亡）。 的 寄生虫多胺代谢的独特属性和机会 将讨论这些治疗方案（寄生虫）。

DESCRIPTION (Applicant's Description) The polyamines are small aliphatic cations essential for cell growth and viability. The abundant naturally occurring polyamines are spermidine and spermine, along with the diamine precursor, putrescine. Maintenance of pools is complex, and depends on biosynthesis, catabolism and transport. Abnormal accumulations are associated with disturbances of cell growth, including cancer. Therapeutic intervention in polyamine metabolism using inhibitors of key enzymes and analogs is effective in African sleeping sickness and in animal tumor models. Such modalities are under investigation as promising antitumor agents in chemotherapeutic and chemopreventive clinical trials. This proposal is submitted to secure partial funding for the Gordon Research Conference on Polyamines. The meeting will provide a venue for the free exchange of ideas among investigators spanning the spectrum of interests from basic cell science to clinical application. The topics that receive particular emphasis in this program are those that reflect recent advances in the field. Sessions will be offered in the following areas: Studies of intact organisms subject to alteration or ablation of complex regulatory processes provides insight into the in vivo functions of those processes (Transgenic Mice, Mouse Genetics). The role of polyamines in cancer and the use of polyamine analogs and inhibitors of key enzymes will be explored (Cancer). Recent advances in understanding the structure of enzymes of polyamine metabolism have provided insight into their mechanisms of function and potential intervention strategies (Structure). Polyamine functions in intact organisms and in post-transcriptional regulation will be explored (Translational and Post-Translational Regulation, Polyamine Function). The role of polyamines in programmed cell death and in membrane-associated functions will be described (Ion Channels and Transport, Apoptosis). The unique attributes of polyamine metabolism in parasites and the opportunities these offer for therapy will be discussed (Parasites).