PARAHIPPOCAMPAL REGION--BASIC AND CLINICAL IMPLICATIONS

描述（改编自申请人的摘要）：The纽约科学院 科学正在赞助一个会议，题为：“海马旁区：基础 科学和临床意义”，华盛顿，华盛顿特区，1999年9月。的 首席研究员兼主席是Helen Scharfman博士，部门负责人， 海伦·海斯医院神经病学研究中心助理教授， 哥伦比亚大学药理学和神经病学系。共同主席 是门诺维特博士，自由大学解剖学系教授， 荷兰和Robert Schwarcz博士，神经科学项目负责人， 马里兰州精神病学研究中心，精神病学系教授 和药理学，马里兰州大学。 颞叶的几个结构在大脑中起着关键作用 功能，如学习和记忆，情绪和复杂的行为 流程.其中包括海马体，最常被研究的结构 在颞叶和并列的海马旁区， 包括内嗅皮层、嗅周皮层和海马旁皮层。 在过去的十年中，越来越清楚的是， 海马旁区的变化发生在几个早期阶段， 灾难性的神经和精神疾病，如阿尔茨海默氏症 精神分裂症和癫痫。因此，很可能 海马旁神经病理学有助于这些功能障碍，也许 其他脑部疾病值得注意的是，海马旁区域的病理学可能是 这些疾病的一个关键因素，无论疾病的状态如何， 海马体 这次会议旨在将过去的研究与最新信息结合起来 海马旁区的结构和功能一个经常性 主题将是使用这些信息来推进诊断， 治疗使人衰弱的脑部疾病。解剖学，生物化学， 在两种实验动物中进行的生理、行为和病理学研究 人类将由该领域的领导者描述，并将提供一个 对大脑这一重要部分的全面、最新的回顾。 演讲将针对广泛的基础和临床 研究人员和临床医生。将特别强调 吸引妇女和少数民族，并包括个人在广泛的 教育水平。如此多样化的观众将提供最佳的 交流思想的机会，从而确保一个充满活力和 令人兴奋的气氛，在其中令人兴奋的新概念和假设可以 生成的.

DESCRIPTION (Adapted from applicant's abstract): The New York Academy of Science is sponsoring a conference entitled: "The Parahippocampal Region: Basic Science and Clinical Implications" in Washington, D.C. in September, 1999. The principal investigator and chair is Helen Scharfman, Ph.D., Department Head, Neurology Research Center, Helen Hayes Hospital and Assistant Professor, Departments of Pharmacology and Neurology, Columbia University. The cochairs are Menno Witter PhD., Professor, Department of Anatomy, Vrije Universiteit, The Netherlands and Robert Schwarcz, Ph.D., Head, Neuroscience Program, Maryland Psychiatric Research Center, and Professor, Departments of Psychiatry and Pharmacology, University of Maryland. Several structures in the temporal lobe play a critical role in brain functions, such as learning and memory, emotions, and complex behavioral processes. These include the hippocampus, the most frequently studied structure in the temporal lobe, and the juxtaposed parahippocampal region, which is comprised of the entorhinal cortex, perirhinal, and parahippocampal cortex. During the last decade, it has become increasingly clear that pathological changes in the parahippocampal region occur during the early stages of several catastrophic neurological and psychiatric diseases, such as Alzheimer's disease, schizophrenia, and epilepsy. Thus, it is quite likely that parahippocampal neuropathology contributes to dysfunction in these, and perhaps other brain disorders. Notably, pathology in the parahippocampal region may be a critical element of several of these diseases, regardless of the state of the hippocampus proper. This meeting is intended to integrate past studies with the latest information about the structure and function of the parahippocampal region. A recurrent theme will be the use of this information to advance the diagnosis and treatment of debilitating brain disorders. Anatomical, biochemical, physiological, behavioral, and pathological studies in both laboratory animals and humans will be described by the leaders in the field, and will provide a comprehensive, up-to-date review of this important part of the brain. The presentations will be targeted to a wide range of basic and clinical researchers and to clinical practitioners. Special emphasis will be placed on attracting women and minorities, and on including individuals at a wide range of educational levels. Such a diverse audience will provide optimal opportunities for cross-fertilization of ideas, and thus ensure a dynamic and stimulating atmosphere, in which exciting new concepts and hypotheses can be generated.