EUKARYOTIC MRNA PROCESSING CONFERENCE

拟召开的“真核生物的信使核糖核酸加工”会议：将召集科学家研究高等真核生物和酵母中信使核糖核酸的剪接和3‘端加工机制和调控的各个方面。最近在这些领域取得了重大进展，拟议的会议将是一个及时的事件，讨论最新的未发表的结果，并交流想法，治疗促进这一快速发展领域的新发展。拟议的会议将于1999年8月25日至29日举行，这是每隔一年在冷泉港实验室举行的会议的第二次会议。第一次会议于1997年8月20-24日举行，吸引了来自世界各地的272名科学家，他们正在积极研究信使RNA成熟的各个方面，特别是信使RNA的剪接和聚腺苷酸化，但现在范围将略有扩大，包括核信使信使的编辑。会议形式将包括七次全体会议和三次海报会议。将根据提交的摘要挑选全体会议的发言者，这将鼓励初级科学家积极参与。主要内容包括：mRNA剪接和3‘端加工的催化机制和特异性：通过可变剪接和多聚腺化对基因表达的发育和细胞类型的特异性调节；SnRNP颗粒和hnRNPs、SR蛋白质、PRPS和参与多腺化剪接的其他酵母、后生动物和/或植物蛋白因子的结构和功能；剪接体组装；核mRNA编辑；mRNA周转；加工反应、因素、底物和产物的定位和动态，与核结构和核质运输有关。

The proposed conference on "Eukaryotic mRNA Processing": will convene scientists studying various aspects of mRNA splicing and 3'-end processing mechanisms and regulation in higher eucaryote and in yeast. Major advances have recently been made in these areas, and the proposed conference will be a timely event for discussing the latest unpublished results and exchanging idea, therapy fostering new developments in this rapidly moving field. The proposed conference will be held on August 25-29, 199 and is the second meeting of a conference that is held every other year at Cold Spring Harbor Laboratory. The first meeting was held on August 20-24, 1997, and attracted 272 scientists internationally, who are actively investigating various aspects of messenger RNA maturation, particularly mRNA splicing and polyadenylation, but the scope will now be slight expanding to encompass nuclear mRNA editing. The meeting format will consist of seven plenary sessions and three poster sessions. Speakers in the plenary sessions will be will be selected on the basis of the submitted abstracts which will encourage active participation by junior scientists. The main topics covered will include: catalytic mechanisms and specificity of mRNA splicing and 3'-end processing: developmental and cell-type specific regulation of gene expression by alterative splicing and polyadenylation; structure and function of snRNP particles and of hnRNPs, SR proteins, PRPs, and other yeast, metazoan, and/or plant protein factors involved in splicing of polyadenylation; spliceosome assembly; nuclear mRNA editing; mRNA turnover; and localization and dynamics of processing reactions, factors, substrates, and products, in relation to nuclear architecture and to nuclear- cytoplasmic transport.