FASEB RESEARCH CONFERENCE ON BIOLOGICAL METHYLATION

这项申请是为1999年7月16日至7月22日在佛蒙特州学院举行的由美国实验生物学学会联合会(FASE B)主办的名为“生物甲基化”的会议提供部分资金。这将是FASEB关于生物甲基化的第四次两年一次的会议。这些会议几乎是独一无二的，因为它们关注的是全系列的ADOMet依赖的甲基转移酶。对古生菌、真细菌、真菌、植物和动物的基因组序列分析表明，所有基因中的很大一部分指定了ADOMet依赖的甲基转移酶，然而仅仅几年前就发现，尽管没有检测到序列同源性，但大多数这些酶具有共同的核心结构。因此，会议计划旨在促进研究甲基转移酶结构、功能和调控的科学家与那些专注于酶甲基化对从DNA、RNA和蛋白质到有机小分子和金属等各种底物的影响的生物学重要性的科学家之间的富有成效的对话。会议将包括五个发言者会议(21个发言者)，在为期四天的会议中持续展示海报，以及关于外地前沿或有争议的专题的14个系列讲习班，其中至少有30分钟的公开讨论。此外，两个工作坊将专门介绍和讨论由与会者选择的海报，作为最令人兴奋的新作品的范例。这将是这次会议的一个新特点，对于年轻的研究人员以及该领域的新手来说，应该是一个特别好的论坛，以突出他们的研究成果。这一系列关于生物甲基化的会议是讨论DNA甲基化的一个主要会议场所，DNA甲基化学会将继续为其董事会挑选的特殊情况下的海报的演示者的注册费提供部分支持。本次会议将重点介绍生物甲基化的临床和环境应用，以及基础研究。组织者的最终目标是确保所有参与者都有平等的机会以有意义的方式介绍和讨论他们目前的研究，同时延续提供重要领域新发展的专家概述的传统。

This application is for partial funding for a conference called "Biological Methylation" to be held under the auspices of the Federation of American Societies for Experimental Biology (FASEB) at the Vermont Academy from July 16-July 22, 1999. This will be the fourth biennial FASEB conference on biological methylation. These meetings are virtually unique in their focus on the full range of AdoMet-dependent methyltransferases. Analysis of genomic sequences from archaea, eubacteria, fungi plants and animals suggests that a large fraction of all genes specify AdoMet dependent methyltransferases, yet it only a few years since it has been shown that most of these enzymes share a common core structure despite undetectable sequence identity. Thus, the meeting program is designed to promote a productive dialogue between scientists who study methyltransferase structure, function and regulation and those concentrating on biological importance of the effects of enzymatic methylation on a myriad substrates ranging from DNA, RNA and proteins to small organic molecules and metals. The conference will feature five speaker sessions (21 speakers), continual display of posters in a session lasting four days, and a series of 14 workshops on cutting-edge or controversial topics in the field that will include at least 30 min for open discussion. In addition, two workshops will be devoted to presentation and discussion of posters selected by the attendees as examples of the most exciting new work. This will be a new feature of this conference and should be a particularly good forum for younger investigators as well as new comers to the field to highlight their research findings. This series of conferences on biological methylation is a major meeting ground for discussion of DNA methylation and the DNA methylation society will continue to provide partial support for the registration fees of presenters of posters selected by its Board of Directors for special merit. Clinical and environmental applications of biological methylation, as well as basic research, will be highlighted at this conference. The ultimate goal of the organizers is to make sure that all participants have an equal opportunity to have their current research presented and discussed in a meaningful way, while continuing the tradition of providing expert overviews of new developments in important areas.