GORDON CONFERENCE ON ATHEROSCLEROSIS 1999, 2001

本申请是为了部分支持将于1999年6月20日至25日在新罕布什尔州梅里登的金博尔联合学院举行的第14届戈登动脉粥样硬化研究会议。自1971年以来每两年举行一次的国际会议将概述炎症，一氧化氮和脂蛋白受体结构/功能的最令人兴奋的最新进展，因为它们与动脉粥样硬化有关。 动脉粥样硬化发病机制涉及的细胞生物学、分子生物学和结构生物学将被讨论。 重点将放在基因治疗在修改动脉病变的作用;会议计划使用新的动物模型来研究疾病的病因。 计划举办九次会议，内容包括：1.动脉粥样硬化研究的遗传学方法。 2.基因转移技术在血管生成和动脉粥样硬化形成中的应用。 3.炎症、凋亡和动脉粥样硬化之间的分子联系。 4.微生物和免疫在病变进展和消退中的作用。5.清道夫受体生物学与胆固醇转运研究进展。 6.蛋白酶、组织重塑和斑块破裂。 7.研究动脉粥样硬化形成的实验模型。 8.一氧化氮生物学和动脉壁中的信号事件。 9.动脉粥样硬化形成的新见解。这次会议将是动脉粥样硬化研究领域新知识整合的主要工具。 会议计划在会议结束时，与会者将有望更好地了解与动脉粥样硬化相关的生物学过程。 妇女和少数民族将作为会议的领导人和讨论者参加这次会议;来自欧洲的科学家也将作为会议的领导人参加会议。 将尽一切努力让博士后研究员和研究生参加安排在下午举行的张贴海报会议;将请其中一些人就下午会议期间提出的材料主持会后讨论。 这是戈登会议联合主席的严肃意图。Heinecke和G.K. Hansson）介绍新的和年轻的研究人员作为本次会议的发言者，并让他们在本次会议上发挥领导作用。

This application is for partial support of the 14th Gordon Research Conference on Atherosclerosis to be held at Kimball Union Academy in Meriden, New Hampshire on June 20-25, 1999. This international conference, which has been held every two years since 1971, will provide an overview of the most exciting recent developments in inflammation, nitric oxide, and lipoprotein receptor structure/function as they relate to atherogenesis. Cell biology, molecular biology and structural biology involved in the pathogenesis of atherosclerosis will be discussed. Emphasis will be placed on the role of gene therapy in modifying arteriopathy; a session is planned on the use of new animal models to study the etiology of the disease. Nine sessions are planned and will cover: 1. Genetic approaches to the study of atherosclerosis. 2. Use of gene transfer techniques in angiogenesis and atherogenesis. 3. Molecular links between inflammation, apoptosis, and atherosclerosis. 4. Role of microorganisms and immunity in lesion progression and regression. 5. Advances in scavenger receptor biology and cholesterol trafficking. 6. Proteinases, tissue remodeling, and plaque rupture. 7. Experimental models to study atherogenesis. 8. Nitric oxide biology and signaling events in the artery wall. 9. New insights into atherogenesis. This conference will be a major vehicle for the integration of new knowledge in the field of atherosclerosis research. It is planned in such a way that by the end of the conference, the participants will hopefully glean a better understanding of the biological processes associated with atherogenesis. This conference will include women and minorities as session leaders and discussants; scientists from Europe will also participate as session leaders. Every attempt will be made to include post-doctoral fellows and graduate students in the poster sessions scheduled in the afternoons; some of them will be asked to lead post-session discussions on the material presented during those afternoon sessions. It is the serious intention of the Co- chairs of this Gordon Conference (J.W. Heinecke and G.K. Hansson) to profile new and young investigators as speakers in this Conference and for them to have a leadership role at this meeting.