EXERCISE AND DEPRESSION IN ALZHEIMERS DISEASE

描述（改编自研究者摘要）：抑郁症是一种 老年痴呆症（AD）患者在养老院的普遍问题。 抑郁症状和烦躁情绪与功能丧失有关 与AD的阶段不成比例（过度残疾）。 锻炼是一 在抑郁症治疗中显示出希望的现实干预 和烦躁不安的症状 这项研究的长期目标是 是减少由于抑郁症状和烦躁不安 老年痴呆患者的情绪 这一行动的直接目标是 研究的目的是：1）检查16周以上的锻炼对情绪的影响， 老年痴呆症患者的抑郁症状， 2)检查运动超过16周对过度残疾的影响， 患有老年痴呆症的老年人 这项研究将是一个 随机前测后测设计，评分者对治疗不知情。 将对受试者进行抑郁症状预筛选，并随机分配 两组之一：运动（监督步行）或对照组 （社会访问）。 运动组的50名受试者将接受最多30次 每周步行五次，持续四个月。 另一个五十 对照组的受试者将以社会关注的形式获得关注。 一周来五次，每次都一样 抑郁症状 将使用康奈尔痴呆症抑郁量表和情绪进行测量 将使用痴呆情绪评估量表和痴呆 情绪图片测试。 将使用改良ADL测量过度残疾 身体自我维持量表和六分钟步行。 数据 将使用单变量和多变量重复测量进行分析 方差分析 假设的主要检验将针对 群体成员与时间的交互作用。 四组 将检查措施对结果措施的影响， 它们作为协变量在检验假设时的潜在效用： 社会人口统计学指标、药物使用、合并症和严重程度 痴呆 老年痴呆症患者的养老院居民人数正在增加。 最 会变得非常不活跃， 护士的时间 抑郁症加速了自我照顾能力的下降， 养老院居民与AD，增加痛苦和负担， 护理人员，并可能导致并发症，如福尔斯和压力性溃疡。 如果发现有效，这种干预可能有助于维持AD居民 尽可能长时间地在最高层工作

DESCRIPTION (Adapted from the Investigator's Abstract): Depression is a pervasive problem in nursing home residents with Alzheimer's disease (AD). Depressive symptoms and dysphoric mood have been linked to loss of function out of proportion to the stage of AD (excess disability). Exercise is a realistic intervention which shows promise in the treatment of depression and dysphoria in this population. The long term objective for this research is to decrease excess disability due to depressive symptoms and dysphoric mood in nursing home residents with AD. The immediate objectives of this study are to: 1) Examine the effects of exercise over 16 weeks on mood and depressive symptoms in institutionalized elders with Alzheimer's disease and 2) Examine the effects of exercise over 16 weeks on excess disability in institutionalized elders with Alzheimer's disease. This study will be a randomized pretest-postest design with raters blinded to treatment. Subjects will be pre-screened for depressive symptoms and randomly assigned to one of two groups: exercise (supervised walking) or control group (social visits). Fifty subjects in the exercise group will receive up to 30 minutes of walking five times a week for four months. Another fifty subjects in the control group will receive attention in the form of social visits five times a week for the same amount of time. Depressive symptoms will be measured using the Cornell Scale for Depression in Dementia and mood will be measured with the Dementia Mood Assessment Scale and the Dementia Mood Picture Test. Excess disability will be measured using the Refined ADL Scale, The Physical Self-Maintenance Scale, and the Six-Minute Walk. Data will be analyzed using univariate and multivariate repeated measures analysis of variance. The primary test of the hypotheses will be for the interaction effect between group membership and time. Four groups of measures will be examined for their influence on the outcome measures and their potential utility as covariates in testing the hypotheses: sociodemographic measures, use of medications, comorbidity, and severity of dementia. Nursing home residents with AD are increasing in number. Most will become extremely inactive and consume a disproportionately large share of nurses' time. Depression hastens the decline in self-care abilities in nursing home residents with AD, increases distress and burden for caregivers, and may lead to complications such as falls and pressure ulcers. If found effective, this intervention may help to maintain residents with AD at the highest functional level for as long as possible.