Structural insights into adenosine receptors

该项目旨在利用腺苷受体家族作为模型系统，研究G蛋白偶联受体（GPCR）的配体结合和信号转导的潜在机制。这个跨学科的项目将使用结构生物学，药理学和生物化学。预期的结果包括了解四个腺苷受体家族成员的配体选择性。这应该会带来显著的好处，例如基础知识的进步，也可能导致治疗的发展。

This project aims to investigate mechanisms underlying ligand binding and signal transduction at G protein-coupled receptors (GPCRs) by utilising the adenosine receptor family as a model system. This interdisciplinary project will use structural biology, pharmacology and biochemistry. The expected outcomes include understanding ligand selectivity across the four adenosine receptor family members. This should provide significant benefits, such as advancement of fundamental knowledge that could also lead to therapeutic development.