Optical tweezers for bio-nanotechnologies

该项目旨在开发一个由金刚石纳米传感器和新型光学镊子组成的平台，用于在体内和生理相关时间尺度上以单分子分辨率探测细胞过程。在生物医学中，单分子的长期成像是现有生物标签无法实现的。该项目结合了纳米金刚石生物标志物的优越特性（亮度、稳定性、小尺寸和无毒），以及利用激光捕获原子在三维生物环境中操纵纳米金刚石的新型光学镊子。通过实现更小的尺寸和更高的力，该平台将改进生物成像和生物操作技术，并有可能推进病原体追踪和疾病的早期发现。

This project aims to develop a platform of diamond nanosensors and novel optical tweezers for probing cellular processes with single-molecule resolution, in vivo and over physiologically relevant time scales. In biomedicine, long-term imaging of single-molecules is beyond reach with existing bio-labels. The project combines the superior properties of nanodiamond biomarkers (brightness, stability, small size and non-toxicity), with new optical tweezers which exploit laser trapping of atoms to manipulate nanodiamonds in three-dimensional biological environments. By accessing smaller size and higher force regimes, the platform will improve bio-imaging and bio-manipulation techniques, and potentially advance pathogentracking and early detection of diseases.