GERIATRIC LEADERSHIP ACADEMIC AWARD

在这篇文章中描述的老年领导奖的目的 应用的目的是增加范围和有效性， 我们新成立的老龄化研究所 1. 促进我们的研究计划的发展，通过 与学院展开六项合作研究计划 医学院其他部门的成员，以及 与基础科学部门的成员-部门 化学、生物学和海洋生物学 加州大学圣地亚哥分校的海洋学和索尔克的研究人员 院 2. 加强首席研究员的能力， 他作为研究所所长的职责 通过个人培训计划，根据对其他人的访问， 研究所及其主任和研究中心的其他领导人 致力于老年医学或老年学。 3. 扩大我们的教育和培训计划， 老年医学/老年学在医学院，其他 大学和社区的部门。 为了 为了实现这些目标，主要研究者计划 建立在人类遗传学和 特别是分子遗传学在过去 15年来，他一直担任UCSD人类中心主任， 生化遗传学计划。 研究计划将 因此，集中精力确定涉及的遗传因素， 在老化过程中，通过研究（a）体外衰老， 人成纤维细胞，和（B）鉴定生物化学和 导致人类遗传性疾病的遗传缺陷， 加速老化，特别是早老症（Hutchinson-Gilford 综合征）、Werner综合征和Cockayne综合征。 他们将 我也会跟进生化方面的线索， 新的见解发展的退行性疾病的后期 生活，如老年痴呆症。 通过这笔赠款提供的启动资金将允许新的 合作者获得更多所需的初步数据 正式的补助金申请。 目标#3将由 首席研究员利用以下方面的知识和经验： 老年医学和老年学研究中心的其他主任， 作为目标2的一部分，他将访问全国各地。 这笔赠款将大大加快实现以下目标之一 该研究所的长期目标-确定遗传 这些因素很可能会使人容易受到或反对 老年退行性疾病的发展。

The aims of the Geriatric Leadership Award described in this application are directed at increasing the scope and effectiveness of our new Institute for Research on Aging by: 1. Promoting the development of our research program through initiation of six collaborative research plans with faculty members of other departments in the Medical school, as well as with members of basic science departments - Departments of Chemistry, Biology and Marine Biology of the Scripps Institute of Oceanography here at UCSD, and investigators at The Salk Institute. 2. To enhance the ability of the Principal Investigator to carry out his responsibilities as Director of the Institute for Research on Aging by a personal training program based on visits to other institutes and their directors and other leaders in research centers devoted to geriatrics or gerontology throughout the country. 3. Expanding our educational and training programs in geriatrics/gerontology in the School of Medicine, other departments of the University and the community. In order to accomplish these objectives, the Principal Investigator plans to build on the strengths developed in human genetics and in particular, molecular genetics among the faculty during the past fifteen years that he has been Director of the UCSD Human Biochemical Genetics Program. The program of research will thus concentrate on the identification of genetic factors involved in the aging process through studies of (a) in vitro senescence of human fibroblasts, and (b) identification of biochemical and genetic defects responsible for human hereditary diseases of accelerated aging, specifically progeria, (Hutchinson-Gilford syndrome), Werner's syndrome and Cockayne syndrome. They will also follow up biochemical leads that give promise of providing new insight into the development of degenerative diseases of later life, such as Alzheimer's disease. The startup funds provided through this grant will allow new collaborators to obtain the preliminary data required for more formal grant applications. Objective #3 will be facilitated by the Principal Investigator building on the knowledge and experience of other directors of geriatric and gerontology research centers that he will visit throughout the country as a part of objective #2. This grant will substantially accelerate the achievement of one of the Institute's long term goals - the identification of genetic factors that may well confer susceptibility to or against the development of degenerative diseases of later life.