GERIATRIC LEADERSHIP ACADEMIC AWARD

这篇文章描述了老年领导力奖的目标 应用的目的是增加范围和有效性 我们新的老龄化研究所的负责人： 1.通过以下方式促进我们的研究计划的发展 与教职员工启动六项合作研究计划 医学院其他部门的成员，以及 与基础科学系的成员- 斯克里普斯研究所化学、生物学和海洋生物学 加州大学圣迭戈分校的海洋学和索尔克号的调查人员 研究所。 2.提高首席调查员的工作能力 他作为研究所所长的职责 基于访问他人的个人培训计划的老龄化问题 研究所及其所长和研究中心的其他领导 致力于全国各地的老年病学或老年学。 3.扩大我们的教育和培训计划 医学院老年病学/老年学，其他 大学的院系和社区。为了 为实现这些目标，首席调查员计划 建立在人类遗传学和 尤其是过去教职员工中的分子遗传学 他担任加州大学圣迭戈分校人类中心主任已有15年 生化遗传学项目。研究计划将 从而集中精力鉴定所涉及的遗传因素 在衰老过程中通过(A)体外衰老的研究 人成纤维细胞，以及(B)生化和 人类遗传性疾病的遗传缺陷 加速衰老，特别是早衰症(Hutchinson-Gilford 综合征)、Werner综合征和Cockayne综合征。他们会 还跟踪生化线索，承诺提供 对后世退行性疾病发展的新认识 生活，如阿尔茨海默病。 通过这笔赠款提供的启动资金将使新的 合作者将获得更多所需的初步数据 正式的拨款申请。目标3将由 首席调查员基于以下方面的知识和经验 其他老年医学和老年学研究中心主任 作为第二个目标的一部分，他将访问全国各地。 这笔赠款将大大加快实现以下目标之一 该研究所的长期目标--鉴定基因 很可能使人易患或不易患上 晚年退化性疾病的发展。

The aims of the Geriatric Leadership Award described in this application are directed at increasing the scope and effectiveness of our new Institute for Research on Aging by: 1. Promoting the development of our research program through initiation of six collaborative research plans with faculty members of other departments in the Medical school, as well as with members of basic science departments - Departments of Chemistry, Biology and Marine Biology of the Scripps Institute of Oceanography here at UCSD, and investigators at The Salk Institute. 2. To enhance the ability of the Principal Investigator to carry out his responsibilities as Director of the Institute for Research on Aging by a personal training program based on visits to other institutes and their directors and other leaders in research centers devoted to geriatrics or gerontology throughout the country. 3. Expanding our educational and training programs in geriatrics/gerontology in the School of Medicine, other departments of the University and the community. In order to accomplish these objectives, the Principal Investigator plans to build on the strengths developed in human genetics and in particular, molecular genetics among the faculty during the past fifteen years that he has been Director of the UCSD Human Biochemical Genetics Program. The program of research will thus concentrate on the identification of genetic factors involved in the aging process through studies of (a) in vitro senescence of human fibroblasts, and (b) identification of biochemical and genetic defects responsible for human hereditary diseases of accelerated aging, specifically progeria, (Hutchinson-Gilford syndrome), Werner's syndrome and Cockayne syndrome. They will also follow up biochemical leads that give promise of providing new insight into the development of degenerative diseases of later life, such as Alzheimer's disease. The startup funds provided through this grant will allow new collaborators to obtain the preliminary data required for more formal grant applications. Objective #3 will be facilitated by the Principal Investigator building on the knowledge and experience of other directors of geriatric and gerontology research centers that he will visit throughout the country as a part of objective #2. This grant will substantially accelerate the achievement of one of the Institute's long term goals - the identification of genetic factors that may well confer susceptibility to or against the development of degenerative diseases of later life.