BASIC SCIENCE TRAINING IN ENDOCRINOLOGY & IMMUNOLOGY

这项建议旨在提供广泛而全面的科学培训。 在医生的传统研究生研究计划中不可用 进入学术医学。这项建议结合了学术上的 马萨诸塞州大学优秀的研究生课程和研究 理工学院的优势与精湛的临床 马萨诸塞州总医院的环境与基础医学研究 医院。赞助商赫尔曼·N·艾森博士是一位颇有成就的内科医生 具有培养年轻研究人员的杰出经验的科学家。 两个阶段是设想的，紧随其后的，或许是临床 内分泌学方面的奖学金。第一阶段包括研究生水平的课程 麻省理工学院的生物、化学和数学系。研究领域 艾森博士的实验室将以研究抗原受体为中心 T淋巴细胞。本实验室使用的技术可用于 检测受体包括血清学方法和重组 DNA研究阐明了产量亚基的结构。学习如何 使用以下领域中的许多不同工具和过程 免疫学和分子遗传学在全国首屈一指 实验室将为未来的研究提供出色的培训 膜受体。更重要的是，艾森博士的赞助和 实验室和麻省理工学院的学术课程确保了严格的环境 为了成为一名有洞察力的有能力的科学家的过程。进展 在第一阶段期间，将由一个基础科学家委员会进行评估， 致力于医学教育和上述研究领域。 在第二阶段，第一阶段学到的方法将应用于 生理和非生理状态下内分泌系统受体的研究 病理情况。一个可能的第二阶段项目的例子是 淋巴细胞上甲状旁腺激素受体的研究可能的 这些受体的功能和调节提出了许多重要的问题 与临床直接相关。确定的第二阶段赞助商将于#年选出 这项工作将在戴维斯博士的总体指导下进行。 亨利·克罗南伯格、吉诺·瑟奇和约翰·波茨，都是内分泌协会的成员 MGH的单位

This proposal is designed to provide broad and thorough scientific training not available in traditional post-graduate research progrmas for physicians entering academic medicine. This proposal combines the scholarly excellence of graduate coursework and research at the Massachusetts Institute of Technology with the strengths of the superb clinical environment and basic medical research of the Massachusetts General Hospital. The sponsor, Dr. Herman N. Eisen, is an accomplished physician scientist who has had outstanding experience training young investigators. Two phases are envisioned, followed or perhaps split by a clinical fellowship in endocrinology. Phase I involves graduate level coursework in the departments of Biology, Chemistry and Mathematics at MIT. Research in Dr. Eisen's laboratory will center around the study of the antigen receptor of the T lymphocyte. The techniques being used in this laboratory to examine the receptor include serological approaches as well as recombinant DNA studies elucidating the structure of the Yield subunit. Learning to use a number of different tools and procedures from the fields of immunology and molecular genetics in one of the country's foremost laboratories will provide excellent training for future research with membrane receptors. More importantly, Dr. Eisen's sponsorship and laboratory, and the MIT academic offerings ensure a rigorous environment for the process of becoming a discerning competent scientist. Progress during Phase I will be evaluated by a committee of basic scientists with a commitment to medical education and the areas of research noted above. During Phase II, the approaches learned in Phase I will be applied to studying receptors of the endocrine system under both physiological and pathological conditions. An example of a possible Phase II project is the study of parathyroid hormone receptors on lymphocytes. The possible functions and regulation of these receptors raise many important issues of direct clinical relevance. A definite Phase II sponsor will be chosen in the future; such work would proceed under the general guidance of Drs. Henry Kronenberg, Gino Serge, and John Potts, all members of the Endocrine Unit at MGH