MOLECULAR GENETICS TRAINING: RIBOSOMAL GENE EXPRESSION

提出了培养分子遗传学医生的建议。 这项建议将使申请者成为一名多产的、独立的 人类遗传学分子方面的研究人员。解决这些问题的手段 在一个支持性、刺激性的环境中作为研究人员发展 宾夕法尼亚大学人类遗传学系建议。 这项建议中进行的研究将针对 对基因表达转录调控的理解 研究人类核糖体基因的转录。这个 核糖体基因的表达对细胞生长和 发育，并在各种各样的生理和病理改变 条件。了解核糖体基因的转录将 为理解基因表达的变化提供了基础 癌症、衰老、生长和分化。 申请者是一名儿科遗传学家，他将有机会 在分子的指导下进行基础科学训练 遗传学家。申请者的进展将被审查，并指导 由人类遗传学学院委员会提供。委员会将审查 申请人的培训情况，建议继续培训，并评判 完成提案的第一阶段。如所判断的那样，完成该阶段 由委员会，将启动第二阶段和独立的生物 实验。委员会将定期对其工作进行审查 完成并与申请人进行正式和非正式的会晤。

A proposal is made for the training of a physician in molecular genetics. This proposal will prepare the applicant as a productive, independent researcher in the molecular aspects of human genetics. The means for the development as a researcher in a supportive, stimulating environment at the University of Pennsylvania in the Department of Human Genetics is proposed. The research undertaken in this proposal will be directed towards the understanding of transcriptional control of gene expression by investigating the transcription of the human ribosomal genes. The expression of the ribosomal genes is integral to cell growth and development, and is altered in a wide variety of physiologic and pathologic conditions. Understanding the transcription of the ribosomal genes will provide a basis in understanding the alterations in gene expression in cancer, senescence, growth and differentiation. The applicant is a pediatric geneticist who will have the opportunity for training in the basic sciences under the guidance of a molecular geneticist. The applicant's progress will be reviewed, and guidance provided by a Human Genetics Faculty Committee. The committee will review the applicant's training, recommend further training, and judge the completion of Phase I of the proposal. Completion of that phase, as judged by the committee, will initiate Phase II and independent biological experiments. The committee will regularly review that work to its completion and meet with the applicant on a formal and informal level.