PATHOGENESIS AND PREVENTION OF OSTEOPOROSIS

这项计划的项目拨款是用于基础和临床研究 骨质疏松症的发病机制及预防。它包括一个核心 管理、临床服务和数据处理设施 和一个核心组织形态计量学实验室。五大工程 将进行的研究将包括对可能的 雌激素在骨骼中的作用机制及雌激素的作用 前列腺素、细胞因子和生长因子的研究 糖皮质激素对骨细胞功能的影响及其机制探讨 骨质疏松症的遗传决定因素和临床 运动与雌激素预防高血压的比较 绝经后骨质流失。第一年的试点项目将 检查骨量和形态的种族差异， 脊柱侧弯对骨量的影响及治疗方法 使骨细胞永生。该计划项目将是 与骨骼领域正在进行的研究工作相结合 新陈代谢目前在NIH的支持下进行，由许多 上面列出的研究人员以及 康涅狄格大学健康中心。

This program project grant is for basic and clinical studies on the pathogenesis and prevention of osteoporosis. It includes a core facility for administration, clinical services, and data processing and a core histomorphometric laboratory. Five major projects will be undertaken which will include studies on the possible mechanism of action of estrogen in bone and the role of prostaglandins, cytokines, and growth factors, studies on the effect of glucocorticoids on bone cell function, and exploration of the genetic determinants of osteoporosis, and a clinical comparison of exercise and estrogen for the prevention of postmenopausal bone loss. Pilot projects in the first year will examine racial differences in bone mass and morphology, the effects of scoliosis on bone mass, and methods for the immortalization of bone cells. This program project will be integrated with ongoing research efforts in the area of bone metabolism currently carried out with NIH support by a number of the investigators listed above as well as other scientists at the University of Connecticut Health Center.