Determining features that separate groups of protein sequences

该项目旨在开发数学方法，以确定根据氨基酸序列区分一组蛋白质和另一组蛋白质的特征。这组序列将反映不同的结果，因此确定基本特征可以导致针对较差结果的有针对性的干预。在每个位置或已知特征的简单比较可能无法确定鲁棒微分器，因此需要更复杂的方法。例如，该项目将通过比较慢性感染的早期艾滋病毒传播序列来帮助确定艾滋病毒疫苗靶点。这些方法将适用于高突变率使这项任务更加复杂的病毒蛋白质。

This project aims to develop mathematical approaches for determining features that distinguish one group of proteins from another, based on their amino acid sequences. The groups of sequences will reflect different outcomes, so that identifying the fundamental features can result in targeted interventions against the poorer outcome. A simple comparison at each position or of known features can fail to determine robust differentiators and so more complex methods are required. The project will, for example, help identify HIV vaccine targets by comparing early HIV transmission sequences from those in chronic infection. The methods will be applicable to viral proteins where high mutation rates make this task even more complex.