GASTROINTESTINAL FUNCTION--GULATION AND ADAPTATION

这是一份修订后的申请， 多学科项目，旨在调查该条例， 胃肠道（GI）功能的适应。 的第一步和第 项目（P.I.： G.A.卡斯特罗）是为了进一步了解如何 粘膜免疫系统调节上皮细胞和平滑肌功能 及其在生理适应中的作用 适应不良 第二个项目的目标（P.I.： 玛丽·K Haddox）的目的是阐明生物化学和分子机制 负责鸟氨酸脱羧酶的表达和调节 在胃肠道上皮中的活性。 第三个项目（P.I.： L.R. 约翰逊）是P. I.在过去五年中， 年来阐明的作用，鸟氨酸脱羧酶和多胺， 细胞分裂、细胞迁移和细胞-基质相互作用， 对粘膜损伤的愈合过程至关重要。 所有 这些项目将需要继续使用计算核心（C） 在我们目前的PPG奖的支持下， 细胞生物学核心（B）;行政核心（A）将提供秘书服务 为科研项目和科学研究提供服务和财务管理 丹 拟议的研究涉及多学科方法，旨在 解决分子、细胞、组织和器官的重要问题 程度. 这些研究的统一主题是进一步促进我们的 了解胃肠道如何适应环境 以一种综合的方式强调。

This is a revised application for continued support of a programmatic, multi-disciplinary project aimed at investigating the regulation and adaptation of gastrointestinal (GI) function. The objectives of the first project (P.I.: G.A. Castro) are to further our understanding of how the mucosal immune system regulates epithelial cell and smooth muscle functions in the gastrointestinal tract and its role in physiological adaptations and maladaptations. The objectives of the second project (P.I.: Mari K. Haddox) are to elucidate the biochemical and molecular mechanisms responsible for expression and regulation of ornithine decarboxylase activity in gastrointestinal epithelia. The third project (P.I.: L.R. Johnson) is a logical extension of the P.I.'s efforts during the past five years to elucidate the roles of ornithine decarboxylase and polyamines in cell division, cell migration and cell-substrate interactions that are essential for the healing processes in response to mucosal damage. All of these projects will require the continued use of the Computational Core (C) supported by our current PPG Award and extensive use of a newly-established Cytobiology Core (B); the Administrative Core (A) will provide secretarial services and financial management for the research projects and scientific cores. The proposed studies involve a multidisciplinary approach aimed at resolving important questions at the molecular, cellular, tissue and organ levels. The unifying theme of these studies is to further our understanding of how the gastrointestinal tract adapts to environmental stresses in an integrative fashion.