MECHANISMS OF HETEROGENEITY IN THE LUNG

本提案是对我们的计划进行竞争性续订的请求 项目。这项正在进行的研究的下一阶段将解决 影响肺内异质性的机制。 之前的计划涉及到的机制和补偿， 限制通过肺循环的流动。第一个焦点 是关于肺血流受限的原因。有研究表明， ADEMD的形成、缺氧性肺血管收缩和ADEM的机制 自发性梗阻。第二个焦点是对 肺血流受限，特别是支气管的作用 循环，以及对右心压升高的系统反应。 在此基础上，本方案的重点是机制 肺内通气性和灌注性的异质性。七个项目 并提出了三个核心，分别解决了区域内和 区域间的异质性机制。这些项目处理的要么是 通风或灌流分开，两者配合为宜 影响气体交换和影响浮肿的形成。 这种方法是多学科的，调查人员接受过 医学、生理学、麻醉学、生物工程、形态学、 工程学和放射学。这是二十年来人们对 肺生理学和医学以及 调查人员。该计划旨在支持其他研究， 特别是在ARDS和肺血管疾病方面，这一过程正在进行中 在这个机构。这项建议的优点包括 融合了多个学科，这群人的生产力 研究人员和采用新的实验方法 细胞的成像、形态重建及分维评价 异质性。

This proposal is a request for a competitive renewal of our Program Project. The next phase of this ongoing research will address the mechanisms which affect heterogeneity in the lung. The previous program dealt with the mechanisms of, and compensations for, restrictions to flow through the pulmonary circulation. The first focus was on causes of pulmonary blood flow restriction. There were studies of mechanisms of ademd formation, hypoxic pulmonary vasoconstriction and thrornbotic obstruction. The second focus was on cornpensations for pulmonary blood flow restriction, particularly the role of the bronchial circulation, and the systernic response to a raised right heart pressure. Building on this,.the focus of the present program is on the mechanisms of heterogeneity of ventilation and perfusion in the lung. Seven projects and three cores are proposed which address both intraregional and interregional mechanisms of heterogeneity. The projects deal either with ventilation or perfusion separately, the matching of the two as it affects gas exchange and influences on edema formation. The approach is multidisciplinary, with investigators trained in medicine, physiology, anesthesiology, bioengineering, morphology, engineering and radiology. It is a result of two decades of interest in pulmonary physiology and medicine and .collaboration between the investigators. The program is designed to support other research, particularly in ARDS and pulmonary vascular disease, which is proceeding at this institution. The strengths of the proposal include the integration of many disciplines, the productivity of this group of investigators and the adoption of new experimental approaches using imaging, morphological reconstruction and fractal evaluation of heterogeneity.