CENTER FOR CLINICAL RESEARCH IN EPILEPSY

该中心赠款更新代表了多学科的方法 癫痫的临床研究 这里包括的项目有 专门研究复杂部分性癫痫 以及他们的药物管理 项目一是应用 新的临床评价的统计模型 抗癫痫药物（AED）。 项目2涉及 为AED研究开发新的统计方法。 项目 3研究了人类大脑中AED的浓度-反应关系 在癫痫手术中从病人体内取出 项目4 表征并寻找心因性癫痫发作的相关性。 项目5将检查有毒物质形成的确定因素 丙戊酸代谢产物和项目6的影响， 癫痫康复干预。 三大核心管理 协调整个中心的活动， 神经病学的多学科临床研究支持， 神经心理学、护理、社会工作和职业教育 康复活动. 核心生物统计学提供统计学 咨询和数据分析，并支持患者人群 数据库作为所有需要临床研究的研究的资源 患者以及流行病学研究。 核心计算机 设施支持所有统计分析和患者 人口数据库。 这项工作的主要部分将在区域癫痫 中心，一个多学科的临床研究中心，重点是 自1975年以来一直活跃的癫痫。 该中心带来了 对癫痫感兴趣的研究人员， 癫痫发作的难题和治疗癫痫的方法， 为临床研究提供了机会。 这也 为一系列临床研究和研究提供了基础 癫痫病的治疗方法超出了这个范围。 的 该中心的总体目标，该中心赠款更新是为了 继续解决癫痫的主要问题，通过一个多- 三维方法，结合了广泛的临床 研究具有坚实的核心支持基础。

This center grant renewal represents a multidisciplinary approach to clinical research in epilepsy. Projects included here are specifically aimed toward research into complex partial seizures and their drug management. Project 1 is the application of statistical models to actual clinical evaluations of new antiepileptic drugs (AED). Project 2 is concerned with the development of new statistical methods for AED studies. Project 3 examines AED concentration-response relationship in human brain removed from patients during epilepsy surgery. Project 4 characterizes and searches for correlates of psychogenic seizures. Project 5 will examine determinates of the formation of toxic metabolites of valproic acid and Project 6 the effects of intensive intervention on epilepsy rehabilitation. Three Core Administration coordinates overall center activities and provides basic multidisciplinary clinical research support in neurology, neuropsychology, nursing, social work, and vocational rehabilitation. Core Biostatistics provides statistical consultation and data analysis, and supports the Patient Population Data Base as a resource for all studies requiring clinical research patients as well as epidemiological studies. Core Computer facilities support all statistical analysis and the Patient Population Data Base. The major part of this work will be done at the Regional Epilepsy Center, a multidisciplinary clinical research center focusing on epilepsy that has been active since 1975. That center brings together investigators interested in epilepsy, patients with difficult seizure problems and therapeutic approaches for epilepsy, that provide opportunities for clinical research. This has also provided the basis for a range of clinical research and research training programs in epilepsy beyond those of this proposal. The overall goal of that center, and this center grant renewal is to continue to address major problems in epilepsy through a multi- dimensional approach which combines a broad range of clinical research with a strong base of core support.