ASTHMA & ALLERGIC DISEASE CENTER FOR IMMUNODERMATOLOGY

要求继续支持多学科中心， 研究某些皮肤病的基本病理机制， 参与体液或细胞免疫事件， 作为主要或次要表现。 该中心将集中在 研究： 1.皮肤疾病谱内的疾病 血管炎血管性水肿荨麻疹 在这些研究中，我们将尝试 确定可能的生化介质和细胞相互作用， 导致这组疾病的临床表现。 2.临床表现为脑内动脉瘤患者的受体 免疫反应性改变谱。 这些研究将涉及 患者：获得性缺乏综合征、红斑狼疮和 汉森氏病。 有人提出，补体受体可能是 疾病活动的预测标志物。 3.光毒性反应或由于遗传缺陷的卟啉 代谢或药物摄入。 这些疾病提供了一个很好的 补体系统非免疫激活研究模型 和肥大细胞衍生的介质。

Continuation of support is requested for a multidisciplinary center to study the basic pathologic mechanisms of certain skin diseases which appear to have the participation of humoral or cellular immunologic events, either as a primary or secondary manifestation. The center will concentrate in studies of: 1. Diseases within the spectrum of cutaneous vasculitis-angioedema-urticaria. In these studies we will attempt to identify the biochemical mediators and cellular interactions that may be responsible for the clinical manifestations in this group of diseases. 2. Receptors in patients presenting with clinical manifestations within the spectrum of altered immunologic reactivity. These studies will involve patients with: acquired deficiency syndrome, lupus erythematosus and Hansen's disease. It is proposed that complement receptors may be predictive markers of disease activity. 3. Phototoxic reactions either due to genetic defects in phorphyrin metabolism or intake of medications. These diseases offer an excellent model for studies of non-immunologic activation of the complement system and mast cell derived mediators.