PATHOPHYSIOLOGIC & BIOCHEMICAL CHANGES OF THERMAL INJURY

热损伤的病理生理学显然是一种顺序相互作用。 局部(烧伤创面)病理和全身器官功能障碍之间的关系 需要研究持续损伤的综合特征。这些 研究的目的是首先确定伤口中的特定反应 从系统上讲，只有早期的药理学才能改变这一点 干预。确定早期生理性创伤反应的使用 皮瓣室模式、血管反应性、毛细血管通透性、 基质改变和伴随的化学变化(烧伤创面液体 分析)在烧伤创面，并立即全身感染的原因 高血糖和随后的心肌抑制预计会 口述有效的可能的治疗干预措施。其次，本地化 全身清道夫、阻滞剂或强化治疗将会完成 通过脂质体或配体给药系统的设计 量化控制效果。 第三，通过控制早期的病理生理事件与 早期手术切除烧伤创面，立即、永久 报道，我们预计将消除次要事件级联 使系统性故障永久化。最近在舞台上开发的 体外同种异体中厚皮移植将进一步发展和 受雇于中度伤害(不到10%)和严重烧伤 受伤(超过30%的烧伤)。

The pathophysiology of thermal injury is clearly a sequential interaction between local (burn wound) pathology and systemic organ malfunction that requires study of an integrated profile of continuing injury. These studies are designed to first identify specific responses in the wound as well as systemically, that can be altered only by early pharmacologic intervention. Defining the early physiologic wound responses by the use of the skin flap chamber mode, vascular reactivity, capillary permeability, matrix alteration, and the accompanying chemical changes (burn wound fluid analysis) in the burn wound, and the cause of the immediate systemic hyperglycemia and the subsequent myocardial depression is expected to dictate effective the probable therapeutic interventions. Secondly, local and systemic scavenger, blockers or enhancing therapy will be accomplished by the design of liposomal or ligand drug delivery systems for quantitatively controlled effect. Thirdly, by controlling the early pathophysiologic events coupled with early surgical removal of the burn injury and immediate, permanent coverage, we anticipate eliminating secondary cascade of events perpetuating systemic malfunction. The recently developed on stage in vitro homologous split thickness skin graft will be further developed and employed in both moderate injuries (less than 10%) and in major burn injuries (greater than 30% burns).