BASIC MECHANISMS OF SEIZURES

这是一个建议，继续我们的计划项目，题为“基本 癫痫发作的机制”。 本申请描述了一种程序， 代表了我们研究方向和重点的重大变化。 我们实验室最近的研究发现了一类新的 神经活性化学物质--烷基取代的γ-和 硫代丁内酯。 这些化合物似乎具有新的机制， 它们可以调节大脑中神经元兴奋性的作用。 我们 相信神经活性丁内酯和相关化合物具有 巨大的潜在疾病和失调。 因此，我们希望建立一个 主要的研究工作，以了解更多关于这些化合物及其 分子和细胞机制以及作用位点。 目前的方案包括四个组成项目和一个 行政核心。 各组成项目的主要目标是：（1） 研究神经活性丁内酯的化学和化学相关的 化合物：（2）表征神经效应的分子机制 和这些药物的作用部位：（3）确定细胞机制， 神经活性丁内酯和化学相关化合物， 描述了抑制性神经传递的一些机制 哺乳动物神经组织：（4）确定负责的功能解剖学 对于上述化学物质的神经学效应以及对于 癫痫发作 我们目前的计划汇集了一批有才华和生产力的 医学科学家 每个主要调查员都有一个特别的发现 知识和研究技能，使他特别适合 实现我们的研究目标。 他们已经证明， 相互配合，相互指导，密切相关，相辅相成 研究项目。 我们的项目应该提供大量的信息，这将提高我们的 正常和异常的大脑功能的知识，并应导致 更好地理解和改善神经系统疾病的治疗。

This is a proposal to continue our program project entitled "Basic Mechanisms of Seizures". This application describes a program which represents a major change in direction and emphasis in our research. Recent studies in our laboratories have led to the discovery of a new class of neuroactive chemicals -- alkyl substituted gamma- and thiobutyrolactones. These compounds appear to have novel mechanisms of action by which they can regulate neuronal excitability in brain. We believe that neuroactive butyrolactone and related chemical compounds have great potential diseases and disorders. Because of this we wish to mount a major research effort to learn more about these compounds and their molecular and cellular mechanisms and sites of action. The present program consists of four component projects and an administrative core. The major goals of the component projects are: (1) to study the chemistry of neuroactive butyrolactones and chemically related compounds: (2) to characterize the neurologic effects molecular mechanisms and sites of action of these agents: (3) to define cellular mechanisms of neuroactive butyrolactones and chemically related compounds and characterize some of the mechanisms of inhibitory neurotransmission in mammalian nervous tissue: (4) to define the functional anatomy responsible for the neurologic effects of the above chemicals and for the expression of seizures. Our present program brings together a group of talented and productive medical scientists. Each of the principal investigators has a special find of knowledge and research skills which make him particularly suited to carry out our research goals. They have already demonstrated that they work well together and direct closely interrelated and complementary research projects. Our project should provide substantial information that will improve our knowledge of both normal and abnormal brain function and should lead to a greater understanding and improved treatment of nervous system diseases.