CBF AND METABOLISM IN STROKE AND SHOCK

该项目的主要目标可以分为三个主要方面 调查领域a）审查在 在缺血性损伤过程中， B）检查其自身和再灌注阶段期间的潜在的 干预措施，可能会产生有利的影响后， 缺血性事件，和c）研究或正常脑功能，调节 脑血流量和代谢，以及发生在 这些过程在影响大脑的局部缺血条件下。 本应用程序中的项目通过其重点密切相关 为了更好地理解大脑功能的正常控制， 缺血性损伤引起的这些功能的改变 对大脑，造成脑损伤的因素， 发展防止这种损害的手段。 我们所拥有的技术 我们的处置允许使用来看待这些相互关联的问题， 亚细胞水平，斯托克动物模型，人类临床研究。 基础科学家和临床研究人员在这方面的密切互动 程序项目允许从亚细胞研究中获得的信息 和动物模型水平应用于临床情况， 相反，临床重要性的问题可以通过 基础科学家可用的工具。

The major goals of this program project can be divided into three main areas of investigation a) an examination of the factors important in the development of irreversible ischemic damage both during the ischemic insult itself and during the reperfusion phase, b) an examination of potential interventions which may favorable influence the outcome following an ischemic event, and c) studies or normal cerebral function, regulation of cerebral blood flow and metabolism, and the abnormalities that occur in these processes in ischemic conditions affecting the brain. The projects in this application are closely inter-related by their focus on an attempt to better understand the normal control of cerebral function, the alterations that occur in those functions produced by ischemic insults to the brain, the factors responsible for the cerebral damage produced and the development of means to prevent that damage. The techniques we have at our disposal allow use to look at these inter-related problems from the subcellular level, to animal models of stoke, to clinical studies in man. The close interaction of basic scientists and clinical researchers in this program project allows information obtained from studies at the subcellular and animal model levels to be applied to the clinical situation and conversely problems of clinical importance can be explored rapidly with the tools available to the basic scientists.