CBF & METABOLISM IN AGING AND DEMENTIA

痴呆症是老年人残疾的主要原因， 65岁以上人群的患病率为15%。 本研究设计 研究脑结构和功能的变化， 正常衰老和痴呆 了解这些机制将有助于 在制定预防、诊断和治疗认知障碍的策略方面， 人口老龄化的恶化。 近期目标是：（1）评估全球和区域变化 脑血流量（CBF）在老龄化和痴呆;（2）调查 脑血流异常与心理缺陷的关系 痴呆;（3）评估特定认知刺激的效果 正常老年人和痴呆患者的BCF任务;（4）研究BCF与痴呆的关系 老年人脑萎缩和CBF减少之间的关系;和（5） 描述了不同年龄组的区域31 P-NMR光谱模式， 痴呆亚型（阿尔茨海默型、多发性梗死和帕金森型）。 局部脑血流量将使用静脉内 氙-133注入技术，具有以下优点： 非侵入性，已建立和可重复的定量方法， 适用于老年人口时的有效性，以及在 活化研究 受试者将接受严格的评估， 包括无症状颈动脉 非侵入性地评估疾病，以分离 原发性脑实质变性引起的血管改变是脑血流的原因 减少老化。 质子核磁共振成像将作为一种新的和有前途的 脑萎缩和多发性梗死改变评估技术 痴呆（MID）。 一个更新的发展，在体内31 P-NMR光谱， 将被用来测量磷酸盐依赖的区域变化， 生物能量学 所有全球和区域生理和解剖数据 将与一般和特定的心理缺陷相关， 这些科目。 由此获得的信息可能会提高我们对潜在问题的理解。 衰老疾病的病理生理过程，以及未来 努力开发有效的治疗方法。

Dementia is a leading cause of disability among the elderly, with a prevalence rate of 15% in individuals over age 65. This study is designed to investigate changes in cerebral structure and function associated with normal aging and dementia. An understanding of these mechanisms will help in developing strategies to prevent, diagnose, and treat cognitive deterioration in the aging population. The immediate objectives are to: (1) evaluate global and regional changes in cerebral blood flow (CBF) in aging and dementia; (2) investigate the relationship between abnormalities in CBF and psychological deficits in dementia; (3) assess the effects of stimulation with specific cognitive tasks on BCF in normal aging and dementia; (4) study the relationship between cerebral atrophy and CBF reductions in the elderly; and (5) describe regional 31P-NMR spectroscopic patterns in various age groups and dementia sub-types (Alzheimer's type, multi-infarct, and Parkinsonian). Regional cerebral blood flow will be measured using the intravenous Xenon-133 injection technique, which has the advantages of non-invasiveness, established and reproducible quantification methods, validity when applied to an aged population, and ease of implementation in activation studies. Subjects will be rigorously evaluated for the presence of cerebrovascular risk factors including asymptomatic carotid artery disease assessed non-invasively, in order to separate the effect of vascular changes from primary parenchymal degeneration as a cause of CBF reduction in aging. Proton-NMR imaging will be used as a new and promising technique for assessing cerebral atrophy and changes of multi-infarct dementia (MID). An even newer development, in vivo 31P-NMR spectroscopy, will be employed to measure regional variations in phosphate-dependent bioenergetics. All global and regional physiological and anatomical data will be correlated with the general and specific psychological deficits in these subjects. The information thus gained may improve our understanding of underlying pathophysiological processes in disorders of aging, and direct future efforts to develop effective therapeutic modalities.