MAINTENANCE OF A HISTOCOMPATIBILITY MUTANT MOUSE COLONY

这个项目建议维持一群老鼠， 组织相容性基因突变，特别是H-2复合体的突变， 作为一个资源殖民地。初生的突变株，目前在 开发，将完成并添加到收藏。菌株 将被系统地监测以保持他们的基因 完整性，通过皮肤移植和血清学分型。没有更大的了 通过皮肤移植的规模筛选新的突变体将作为 这是这个项目的一部分。然而，未来可能会添加更多的突变体作为 从另一个单独资助的项目中康复，在该项目中，皮肤移植 用于监测NCI小鼠群体的遗传完整性。

This project proposes to maintain a colony of mice bearing histocompatibility gene mutations, particular those of the H-2 complex, as a resource colony. Incipient mutant strains, currently under development, will be completed and added to the collection. Strains maintained will be systematically monitored to maintain their genetic integrity, by skin grafting and by serological typing. No further large scale screening by skin grafting, for new mutants will be carried out as part of this project. however, additional future mutants may be added as recovered from another separately funded project in which skin grafting is used to monitor the genetic integrity of the NCI mouse colonies.