Master of Research in Biomedical Sciences with a specialisation in Integrative Mammalian Biology (IMB) [Systems]

我们提交的标题是“体内技能”。然而，我们将把体内训练与“系统生物学”训练结合起来。这些学生还将培养制药行业需求的技能能力（见下文和“支持案例”）。综合哺乳动物生物学（IMB）体内技能与系统生物学的整合是一种新颖的研究方法，因此，很少有学生接受过这两门学科的培训，因此不具备从事涉及系统生物学和体内技术的博士课程或研究职业的能力。这个硕士培训将提供具有这些技能的新一代年轻科学家，因此将具有独特的地位，要么进行相关的博士学位，要么获得越来越需要具有这些不同技能的研究人员的工业研究实习。附阿斯利康和辉瑞的支持信。学生将攻读知名的生物医学科学研究硕士学位。详情见所附课程文件。格拉斯哥/斯特拉斯克莱德大学是四个“中心”之一，被授予大约ú3m，以建立综合哺乳动物生物学（IMB）研究的能力（由BBSRC， MRC，辉瑞，阿斯利康葛兰素史克，sheefc， HEFC，英国药理学学会资助；M MacLean教授是该计划的PI和主任）。学生们将攻读生物医学科学研究硕士学位，该专业是作为IMB计划的一部分而设立的，是为满足希望学习体内技能的学生的需求而量身定制的。http://www.gla.ac.uk/faculties/fbls/gs/masterscourses/mresinbiomedicalsciencesintegrativemammalianbiology/他们将开展两个项目，将体内哺乳动物生物学与系统生物学结合起来，这些项目将由在研究和培训方面表现卓越的既定工作人员监督。附件“潜在项目”中给出了几个项目的例子。他们还将参加由辉瑞公司的科学家提供的为期半天的研讨会或讲习班，向他们提供系统生物学在药物开发研究中的应用知识（见所附的支持信）。他们将参加imb资助的两所独特的年度暑期学校之一，旨在向全英国的学生传授基本的体内技能（详见“特定技能”）。我们设想这个硕士课程将随着科学和需求的进步而“发展”。例如，将咨询辉瑞公司的课程设计，以配合工业发展（见支持信）。注：为本申请选择的工作人员来自监督生物医学科学研究硕士项目（综合哺乳动物生物学专业）的工作人员，以及为BBSRC/EPSRC细胞与蛋白质组学技术博士培训中心（CPT）做出贡献的系统生物学家。“课程历史”下提供的数据包括这两门课程的学生，这两门课程的课程信息文件作为附件提交。为了清楚起见，参考“课程历史”：2006年有28名学生开始攻读学士学位，7名学生开始攻读CPT；2007年，30人在BS工作，7人在CPT工作；2008年，36人在BS工作，5人在CPT工作。

We are submitting under the heading 'in vivo skills'. However we will integrate the in vivo training with training in 'systems biology'. These studentships will also build capacity in skills for which there is demand within the pharmaceutical industry sector (see below and 'Case for Support'). The integration of integrative mammalian biology (IMB) in vivo skills with systems biology is a novel approach to research and as such, very few students are trained in both disciplines and so are ill-equip to embark on a PhD programme or research career that involves both systems biology and in vivo techniques. This Masters training will provide a new generation of young scientists that have these skills and will therefore be uniquely placed to either carry out a related PhD or obtain industrial research placements that will increasingly require researchers with these diverse skills. Letters of support from AstraZeneca and Pfizer are attached. Students will enrol in the well established Master of Research in Biomedical Sciences. See attached course document for details. Glasgow/Strathclyde Universities were one of four 'centres' to be awarded circa ¿ú3m to build capacity in Integrative Mammalian Biology (IMB) studies (Funded by BBSRC, MRC, Pfizer, AstraZeneca GlaxoSmithKline, SHEFC, HEFC, British Pharmacological Society; Prof M MacLean is PI and director of this initiative). The students will take the Master of Research in Biomedical Sciences with the specialisation in IMB which was set up as part of the IMB initiative and is tailor-made to meet the needs of students wishing to learn in vivo skills. http://www.gla.ac.uk/faculties/fbls/gs/masterscourses/mresinbiomedicalsciencesintegrativemammalianbiology/ They will carry out two projects that will integrate in vivo mammalian biology with systems biology and these will be supervised by established staff selected for excellence in research and training. Examples of just a few projects are given in the attachment 'Potential projects'. They will also attend a half-day seminar or workshop which will be provided by scientists from Pfizer to provide them with knowledge of the application of systems biology to drug development research (see attached letter of support). They will attend one of the two unique annual IMB-funded summer schools designed to educate students throughout the UK in basic in vivo skills (see under 'specific skills' for more details. We envisage that this Masters course will 'evolve' with advances in science and with demand. For example Pfizer will be consulted about the design of the course in line with developments in industry (see letter of support). Note: The staff selected for this application have been drawn from staff who supervise projects for the Master of Research in Biomedical Sciences (specialisation in Integrative Mammalian Biology (BS)) as well as systems biologists contributing to the BBSRC/EPSRC Doctoral Training Centre in Cell & Proteomic Technologies (CPT). The data provided under 'Course History' includes students enrolling into both these courses and the Course Information Documents for both courses are submitted as attachments. For clarity, in reference to 'Course History': In 2006 28 students started in BS, 7 in CPT; in 2007 30 started in BS, 7 in CPT; in 2008 36 started in BS, 5 in CPT.