DEMENTIA IN THE BLACK AGED--AD AND MID

描述：(改编自申请者摘要)阿尔茨海默病(AD) 和多发性梗死性痴呆(MID)是进展性痴呆的两个主要原因 以及不可逆转的痴呆症。确定与AD相关的风险因素和 MID是寻找病因和干预的重要一步 和预防策略。这项研究的主要目的 应用程序是识别和澄清AD和MID的风险因素 城市黑人老年人口。黑人的比例一直偏低。 痴呆症的生物医学、行为和心理社会研究。这个 调查人员建议研究流行病学、医学、神经心理学 和神经放射学特征进行病例对照研究 在两组索引案例中，患有AD的黑人和患有MID的黑人和 对照组由黑人多发性脑梗塞组成，但 没有认知障碍。 该项目的第二个主要目标是跟踪病例控制。 从纵向上确定认知能力下降的速度 状态，以确定和比较测量认知和 黑人AD和MID患者的功能状态和死亡率 描述这些变量随着时间的推移的历史，并发展 关于医学和心理社会因素的假说 美国黑人老龄化的生存劣势。 第三个主要目标是积累足够的标准化 应用神经病理学对死亡病例进行神经病理学观察 CERAD制定的标准用于验证AD的临床诊断和 阐明黑人MID的有效标准。调查人员提议 以收集危险因素经验数据为前奏的病例对照研究 有针对性的干预研究的设计。

DESCRIPTION: (Adapted from Applicant's Abstract) Alzheimer's disease (AD) and multi-infarct dementia (MID) are the two leading causes of progressive and irreversible dementia. Identifying risk factors associated with AD and MID is an important step in the search for etiology as well as intervention and prevention strategies. The major objective of this research application is to identify and clarify risk factors for AD and MID in an urban black aged population. Blacks have been underrepresented in biomedical, behavioral and psychosocial studies of dementia. The investigators propose to study epidemiological, medical, neuropsychological and neuroradiological characteristics by carrying out a case-control study in two groups of index cases, blacks with AD and blacks with MID, and a control group composed of blacks with multiple cerebral infarcts but without cognitive impairment. The second major objective of this project is to follow the case-control populations longitudinally to determine the rate of decline in cognitive status, to determine and compare outcome variables measuring cognitive and functional status, and mortality among black AD and MID cases with respect to descriptive history of these variables over time, and to develop hypotheses about medical and psychosocial factors that contribute to the survival disadvantage of aging black Americans. A third major objective is to accumulate enough standardized neuropathological observations on deceased cases using neuropathological criteria developed by CERAD to validate clinical diagnoses of AD and clarify valid criteria for MID in blacks. The investigators are proposing a case-control study to gather empirical data on risk factors as a prelude to the design of targeted intervention studies.