Agronomic processes to optimise galanthamine content of daffodil biomass (AGROGAL)

该项目旨在建立在先前由Alzeim与IGER合作进行的为期一年的研究的基础上，在该研究中，在选定的环境制度和不同的收获日期下考虑了水仙种植的可行性（Morris et al . 05）。当时，由于含有加兰他明的药物受到专利保护，而且由于提取和运输成本高，API水平相当低，因此预计经济回报只会适中。含有原药成分的配方现在是通用的，本提案中详细的研究将建立在连续收获不同的水仙组织的基础上，这些组织含有明显更高的加兰他明水平，已经在阿尔泽姆进行了试点。本项目将探讨的发现和研究将寻求进一步降低成本，方法是应用最新的生物炼制原理，结合全新的收获和提取制度，然后与农学的发展、植物遗传资源的选择和通过减少原料运输节省成本相结合。生物炼制“侧流”的销售应通过提供支持旅游业的产品（香水、纸张、蜡），为当地经济带来附带效益。尽管这项研究的重点是最大化水仙花的生物碱含量，但它也将提供一些信息，这些信息可以被花卉种植者直接利用，也可以被其他寻求利用植物作为次生代谢物来源的生产者间接利用。具体来说，这项研究将展示种植者对气候变化的反应。由研究产生的创新性定性模型应捕获所有预先存在的知识，并对各种试验的结果提供连贯的测试。此外，它们应该为类似系统的模型提供基础。定性模型应使潜在种植者能够确定其投资的预期回报。

This project aims to build on a previous one-year study undertaken by Alzeim in collaboration with IGER, where the feasibility of Narcissus cultivation was considered under selected environmental regimes and at different harvest dates (Morris et al 05). At that time, the economic returns were forecast to be only moderate, since pharmaceuticals containing galanthamine were protected by patents and API levels were quite low allied to high extraction and transport costs. Formulations containing the API are now generic and the research detailed in this proposal will build on sequential harvesting of different Narcissus tissues, containing significantly higher galanthamine levels, already piloted at Alzeim. The findings and research that will be addressed within this project will seek to further drive down costs by applying the latest biorefinery principles, coupled to entirely novel harvest and extraction regimes, which are then allied to developments in agronomy, choice of plant genetic resources and savings through reduced transport of feedstocks. Sales of the biorefinery 'side-streams' should result in spin-off benefits to the local economy through supply of products to support the tourism industry (perfume, paper, wax). Although focused on the objective of maximising the alkaloid content of daffodils, the research will also provide information that can be directly utilised by flower growers and indirectly by other producers seeking to use plants as sources of secondary metabolites. Specifically, the research will demonstrate the response required from growers to climate change. The innovative qualitative models produced by the research should capture all pre-existing knowledge and provide coherent tests of the results of the various trials. In addition, they should provide the foundation for models for analogous systems. The qualitative models should enable prospective growers to determine the expected returns on their investments.