New synthetic strategies to small cyclic peptides

该项目旨在发明新的合成策略，使小环肽能够进行化学操作，小环肽是一类具有高代谢稳定性的有前景的生物活性分子。理论和实践相结合，该项目将开发新型的酰基转移反应，使小环肽的无痕迹、位置选择性、扩环和收缩成为可能。该项目将导致新的合成方法，将简化一类重要的小类药物分子的合成。这将带来显著的好处，例如小环肽合成方法的突破，这将加强澳大利亚在多肽研究方面的国际地位，并为不断增长的生物技术行业提供新的翻译策略。

This project aims to invent new synthetic strategies that enable chemical manipulation of small cyclic peptides, a promising class of biologically active molecules with high metabolic stability. Combining theory and practice, this project will develop novel acyl transfer reactions that will allow traceless, site-selective, ring expansion and contraction of small cyclic peptides. This project will result in new synthetic methodology that will simplify the synthesis of an important class of small drug-like molecules. This will provide significant benefits, such as a breakthrough in the synthetic approach to small cyclic peptides, which will strengthen Australia’s international standing in peptide research and provide new strategies for translation to the growing biotechnology industry.