High resolution phylogenetic analysis of livestock-associated Staphylococcus aureus.

了解牲畜地方病出现的基础对于设计新的防治办法和防止新病原体的出现至关重要。特别是，迄今为止，还没有很好地研究工业化和全球化等人类活动在病原体演变中的作用。金黄色葡萄球菌（Staphylococcus aureus）是人类的主要病原菌，也是奶牛、绵羊、山羊、家禽和猪等养殖动物的重要病原菌，给人类造成了巨大的经济损失。最近的研究提供了证据，S。影响牲畜的金黄色葡萄球菌菌株是从人类菌株进化而来的，并经历了遗传适应，导致动物的地方病。此外，一些与牲畜有关的菌株有能力引起人类的人畜共患病感染。本项目将利用高通量测序技术对畜禽相关沙门氏菌进行全面的遗传分析。金黄色。该项目将揭示与家畜相关的S.金黄色葡萄球菌，它们如何适应动物宿主，以及它们引起人类感染的潜力。遗传分析还将有助于确定目标，以制定控制地方性牲畜疾病的新办法。总体而言，该项目将为关键的动物福利，食品安全和公共卫生问题提供重要的新见解。

An understanding of the basis for the emergence of endemic diseases of livestock is critical for designing new approaches for their control and to prevent new pathogens from emerging. In particular, the role of human activities such as industrialization and globalization in the evolution of pathogens has not been well examined to date. Staphylococcus aureus is notorious as a major human pathogen and is also an important pathogen of farmed animals including cows, sheep, goats, poultry and pigs, resulting in huge economic losses. Recent studies have provided evidence that S. aureus strains affecting livestock have evolved from human strains and have undergone genetic adaptation to cause endemic diseases of animals. Furthermore, some livestock-associated strains have the capacity to cause zoonotic infections of humans. In the current project we will use high throughput sequencing technology to achieve a comprehensive genetic analysis of livestock-associated S. aureus. The project will reveal the evolutionary origin of livestock-associated S. aureus, how they have adapted to animal hosts, and their potential to cause human infections. The genetic analyses will also facilitate the identification of targets for developing new approaches to controlling endemic livestock disease. Overall, the project will contribute important new insights into a critical animal welfare, food security and public health issue.