TOTAL SURGICAL REPLACEMENT OF THE HUMAN HIP JOINT

这项建议涉及：(1)骨重塑和相关 股骨柄植入术后股骨近端结构的变化 非骨水泥型全髋关节置换术中的多孔涂层股骨假体 骨水泥型人工全髋关节翻修术 带涂层的股骨假体。 骨长入固定的前提是假体将保持 无限期地牢牢固定在宿主骨骼上。因此，并发症 由于骨质疏松症是长期关注的主要问题之一。这个 多孔涂层的位置和阀杆的硬度是两个影响因素 可能影响机械环境的设计参数， 因此，无骨水泥多孔后股骨近端的重塑 涂层THA。一个犬类模型将被用来提供关于 这两个参数对骨重塑和骨结构变化的影响 无水泥THA。 据报道，无菌松动的放射证据也很高。 在失败的骨水泥全髋关节翻修术中，AS为40%。无水泥多孔 涂层假体正被用于翻修关节成形术，但它不是 已知在这种情况下是否真的发生了骨内长，也不知道 已知对骨骼重塑的长期影响。犬类修订模型和 犬宿主骨与多孔骨界面处的缝隙模型 涂层将被用来洞察骨骼向内生长的过程， 研究增强这一过程的可能性，并转化为皮质骨 非骨水泥翻修术后的重塑。

This proposal is concerned with: (1) bone remodeling and associated structural changes in the proximal femur subsequent to implantation of porous coated femoral components in cementless total hip arthroplasty (THA) and (2) revision of failed cemented total hip arthroplasty with porous coated femoral components. The premise of bone ingrowth fixation is that the prosthesis will remain firmly anchored to the host bone indefinitely. Consequently, complications due to bone remodeling contitute one of the major long-term concerns. The location of the porous coating and the stiffness of the stem are two of the design parameters likely to influence the mechanical environment and, hence, remodeling of the proximal femur subsequent to cementless porous coated THA. A canine model will be used to provide data on the effect of these two parameters on bone remodeling and structural changes following cementless THA. Radiographic evidence of aseptic loosening has been reported to be as high as 40% in cemented revision of failed cemented THA. Cementless porous coated prosthesis are being used for revision arthroplasty, but it is not known if bone ingrowth actually occurs in this situation nor are the long-term effects on bone remodeing known. A canine revision model and a canine model of a gap at the interface between the host bone and the porous coating will be used to provide insight into the process of bone ingrowth, into the possibility of enhancing this process, and into cortical bone remodeling following cementless revision THA.