REGULATION OF THYROID FUNCTION T4 AND T3 KINETICS

拟议的研究是首席调查员的 主要研究方向：1.老年人的外周代谢 甲状腺激素，特别是人和啮齿动物的生理作用 胎盘对甲状腺激素经胎盘途径的调节作用 TBG的体内生成和营养调控及脱碘 在瘦削和遗传性肥胖的Zucker大鼠体内的碘甲状腺原氨酸； 用~(125)I-Triac作为探针对大鼠T_3核受体进行定量 组织和人体外周血淋巴细胞在各种情况下的异常 甲状腺状态与非甲状腺状态；3.两者之间的相互关系 神经肽(神经降压素(NT)和P物质(SP)以及最近的 描述了有效的内源性阿片肽(德吗啡)与TRH和 甲状腺激素对下丘脑体内TSH分泌的调控 NT、SP和地吗啡的微量注射及其在体外的应用 下丘脑碎片；4.高碘对甲状腺功能的影响 在接受胺碘酮和锂治疗的患者中以及在自发的 发生自身免疫性淋巴细胞性甲状腺炎的糖尿病BB/W大鼠(LT； 将尝试增强或减弱BB/W大鼠的LT 因低碘或高碘摄入而转移的或自发性糖尿病 以及他巴唑的管理，这似乎是一种 甲状腺淋巴细胞的免疫抑制药。这些努力应该进一步 对成人和胎儿甲状腺功能调节的认识 在正常和病理情况下，并与 我们实验室以前和现在的活动。

The proposed studies are a continuation of the principal investigator's research interests in 5 areas: 1. the peripheral metabolism of the thyroid hormones especially the physiologic role of the human and rodent placenta in modulating the transplacental passage of the thyroid hormones in vivo and the nutritional control of TBG generation and the deiodination of the iodothyronines in the lean and genetically obese Zucker rat; 2. the use of 125I-Triac as a probe to quantitate the T3 nuclear receptor in rat tissues and human peripheral lymphocytes under a variety of abnormal thyroid and non-thyroid states; 3. the interrelationship between two neuropeptides (neurotensin (NT) and substance P (SP) and a recently described potent endogenous opioid peptide (dermorphin) with TRH and the thyroid hormones in the control of TSH secretion in vivo by hypothalamic microinjections of NT, SP and dermorphin and in vitro using pituitary and hypothalamic fragments; 4. the effect of excess iodide on thyroid function in patients receiving amiodarone and lithium and in the spontaneous diabetic BB/W rat who develops autoimmune lymphocytic thyroiditis (LT; 5. attempts will be made to enhance or attenuate LT in the BB/W rat with transferred or spontaneous diabetes mellitus by low or high iodine intake and the administration of methimazole which appears to be an immunosuppressant of the thyroid lymphocyte. These efforts should further our understanding of the regulation of adult and fetal thyroid function under normal and pathological conditions and are directly related to previous and present activities in our laboratory.