Magnetofection In An Oscillating Magnetic Field

基因工程的成功很大程度上取决于转染剂传递基因的能力。低转染效率现在被广泛认为是成功传递基因的关键瓶颈。最近对纳米级递送剂发展的重视导致了新的基于物理和化学的技术，这些技术利用了电荷相互作用和能量过程。这个多学科项目旨在通过开发一种在振荡磁场影响下操纵纳米粒子的新方法来解决这个高度重要的问题，从而在高度相关的表观遗传重编程模型中实现高转染效率。

The success of genetic engineering is largely dependent on the ability of transfection agents to deliver genes. Low transfection efficiency is now widely recognised as a critical bottleneck to successful gene delivery. The recent emphasis on the development of nanoscale delivery agents has led to new physics and chemistry-based techniques, which take advantage of charge interactions and energetic processes. This multidisciplinary project aims to address this highly significant problem by developing a novel methodology to manipulate nanoparticles under the influence of an oscillating magnetic field to achieve high transfection efficiencies in a highly relevant model of epigenetic reprogramming.