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ANALYSIS OF THE SHOPE PAPILLOMA-CARCINOMA SYSTEM

ANALYSIS OF THE SHOPE PAPILLOMA-CARCINOMA SYSTEM
SHOPE 乳头状瘤-癌系统的分析
批准号：
3164873
负责人：
FELIX O WETTSTEIN
金额：
$15.71万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
1976
资助国家：
美国
项目状态：
已结题
起止时间：
1976-06-30 至 1987-06-30
来源：
https://reporter.nih.gov/project-details/3164873
关键词：
Shope papilloma affinity chromatography carcinoma cell differentiation clone cells cocarcinogen density gradient ultracentrifugation gel electrophoresis genetic manipulation genetic translation host neoplasm interaction immunochemistry immunofluorescence technique neoplasm /cancer immunology rabbit papillomavirus radiotracer simian virus 40 viral carcinogenesis virus DNA virus RNA virus antigen virus genetics virus replication

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中文摘要
翻译
Shope乳头状瘤-癌系统在定义 与肿瘤过程相关的基本现象。 这是真的，因为在 在家兔中，存在病毒诱导的从正常皮肤到 乳头状瘤到癌。 病毒基因组在所有肿瘤中是保守的，但 病毒没有被制造出来。 我们建议定性和定量地确定 病毒基因产物在两种肿瘤中存在的程度。 这 开始的努力最终应导致对 病毒及其基因产物在诱导和维持良性和 恶性肿瘤
英文摘要
The Shope papilloma-carcinoma system has great potential in the definition of basic phenomena associated with the neoplastic process. This is true since, in the domestic rabbit there is a viral induced progression from normal skin to papillomas to carcinomas. The viral genome is conserved in all neoplasms, but virus is not made. We propose to qualitatively and quantitatively determine the extent to which viral gene products are present in the two neoplasms. This beginning effort should ultimately lead to a definition of the precise role of the virus and its gene products in induction and maintenance of benign and malignant neoplasms.
期刊论文(2)
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会议论文
Integrated shope virus DNA is present and transcribed in the transplantable rabbit tumour Vx-7.
整合的 Shope 病毒 DNA 存在于可移植兔肿瘤 Vx-7 中并进行转录。
DOI： 10.1099/0022-1317-60-2-271
发表时间： 1982
期刊： The Journal of general virology
影响因子： --
作者： [McVay,P, Fretz,M, Wettstein,F, Stevens,J, Ito,Y]
通讯作者： Ito,Y
Transcription of the viral genome in papillomas and carcinomas induced by the Shope virus.
肖普病毒诱导的乳头状瘤和癌中病毒基因组的转录。
DOI： 10.1016/0042-6822(81)90517-1
发表时间： 1981
期刊： Virology
影响因子： 3.7
作者： [Wettstein,FO, Stevens,JG]
通讯作者： Stevens,JG
DEVELOPMENT OF VACCINES AGAINST PAPILLOMAVIRUSES
DEVELOPMENT OF VACCINES AGAINST PAPILLOMAVIRUSES
DEVELOPMENT OF VACCINES AGAINST PAPILLOMAVIRUSES
IMMUNOLOGY OF VIRUS INDUCED PAPILLOMAS/CARCINOMAS
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