Selective anion transporters with therapeutic potential

该项目旨在开发能够选择性地促进阴离子（如氯离子或碳酸氢根）穿过脂质双层膜的化合物。 目前的几代转运蛋白已被证明是非选择性的，转运质子、氢氧化物或脂肪酸头基沿着感兴趣的阴离子。 将开发新的策略来构建选择性转运蛋白，包括使用包封结合位点和动态共价方法来结合以产生选择性系统。这些转运蛋白具有潜在的应用前景，可以作为研究脂质双层转运过程的电生理工具。

This project aims to develop compounds that can selectively facilitate the transport of anions such as chloride or bicarbonate across lipid bilayer membranes. Current generations of transporters have been shown to be un-selective, transporting protons, hydroxide or fatty acid head groups along with the anion of interest. New strategies will be developed to construct selective transporters including using encapsulating binding sites and dynamic covalent approaches to binding to produce selective systems. These transporters have potential future application as electrophysiological tools to study lipid bilayer transport processes.